Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MATURATION OF FETAL HUMAN NEURAL XENOGRAFTS IN THE ADULT-RAT BRAIN
Autore:
BELKADI AM; GENY C; NAIMI S; JENY R; PESCHANSKI M; RICHE D;
Indirizzi:
FAC MED,INSERM,U421,IM3,8 RUE GEN SARRAIL F-94010 CRETEIL FRANCE FAC MED,INSERM,U421,IM3 F-94010 CRETEIL FRANCE HOP ESQUIROL F-94400 ST MAURICE FRANCE
Titolo Testata:
Experimental neurology
fascicolo: 2, volume: 144, anno: 1997,
pagine: 369 - 380
SICI:
0014-4886(1997)144:2<369:MOFHNX>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEGENERATION MUTANT MOUSE; EMBRYONIC PURKINJE-CELLS; PARKINSONS-DISEASE; DOPAMINE NEURONS; VENTRAL MESENCEPHALON; HUNTINGTONS-DISEASE; STRIATAL GRAFTS; ATHYMIC RATS; TRANSPLANTATION; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Belkadi et al., "MATURATION OF FETAL HUMAN NEURAL XENOGRAFTS IN THE ADULT-RAT BRAIN", Experimental neurology, 144(2), 1997, pp. 369-380

Abstract

Transplantation of human fetal neural cells has been used for severalyears as a treatment for Parkinson's disease. These therapeutic trials were based on a large number of rat allografts studies, and the species to species extrapolation appeared valid in many respects. One major difference between neurons of various species, however, is their rate of maturation; indeed, human neurons have been proven to grow much more slowly than rat neurons. This has been studied mostly, up to now, at the light microscope level. In an attempt to determine the fine structural correlates of this protracted development and to detail the schedule of morphogenesis and synaptogenesis, human fetal brain stem tissue (at 8 weeks of gestation) was transplanted into a previously lesioned brain area of immunosuppressed adult rats. Transplants, which wereallowed to develop for 15 days to 3 months, were analyzed using the electron microscope. At 15 days, small cells containing a large nucleuswere surrounded by wide extracellular spaces. At 1 month, grafted neurons displayed a thin rim of cytoplasm and few thin processes. At 2 months, extracellular spaces tended to diminish. Thin processes formed bundles and large processes extended from enlarged neurons. Major changes were observed at 3 months survival as the neuropile filled up with cells and processes and synaptogenesis began. Comparison with a similar ultrastructural study of thalamic rat allografts shows that human cells develop following a pattern similar to that in rat cells but that the duration of each maturation step is largely extended. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:26:38