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Titolo:
Effect of oral ketamine on secondary hyperalgesia, thermal and mechanical pain thresholds, and sedation in humans
Autore:
Mikkelsen, S; Jorgensen, H; Larsen, PS; Brennum, J; Dahl, JB;
Indirizzi:
Univ Copenhagen Hosp, Dept Anesthesiol, Lab Pain Physiol, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark Univ Copenhagen Hosp, Rigshosp, Dept Neurosurg, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark
Titolo Testata:
REGIONAL ANESTHESIA AND PAIN MEDICINE
fascicolo: 5, volume: 25, anno: 2000,
pagine: 452 - 458
SICI:
1098-7339(200009/10)25:5<452:EOOKOS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONIST; D-ASPARTATE ANTAGONIST; NEUROGENIC HYPERALGESIA; SPINAL-CORD; POSTHERPETIC NEURALGIA; HEAT INJURY; DORSAL HORN; NEURONS; RAT; DEXTROMETHORPHAN;
Keywords:
oral ketamine; hyperalgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Mikkelsen, S Univ Copenhagen Hosp, Rigshosp, Dept Anesthesiol 4132, DK-2100 Copenhagen,Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 gen,Denmark
Citazione:
S. Mikkelsen et al., "Effect of oral ketamine on secondary hyperalgesia, thermal and mechanical pain thresholds, and sedation in humans", REG ANES PA, 25(5), 2000, pp. 452-458

Abstract

Background and Objectives: Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist, and has been proven effective in alleviating secondary hyperalgesia in human subjects when injected intravenously. After oral ingestion, ketamine is metabolized into norketamine, which in vitro possesses NMDAreceptor antagonistic effect. The aim of this study was to investigate theeffects of oral administration of ketamine on secondary hyperalgesia evoked by standardized tissue injury. Methods: Twenty-four male volunteers were included in the study. Each volunteer received the following treatment regimen, in randomized, double-blind, 3-way cross-over fashion: (A) placebo; (B) ketamine, 0.5 mg/kg; and (C) ketamine, 1.0 mg/kg. Standardized tissue injury was induced after study medication by heating the right calf with a rectangular thermode. The temperature was 47 degrees C, and heating time was 7 minutes. The following parameters were investigated: Pain during induction of the burn injury; heat-pain detection thresholds in the injured area and a corresponding noninjured area; secondary hyperalgesia surrounding the injured area on the calf: secondary hyperalgesia induced by heating an area on the thigh with 45 degrees C in3 minutes; pressure-pain detection thresholds measured on the middle phalanx of the 4th left finger; pain during a 60-second thermal stimulation of 46 degrees C on undamaged skin on the left thigh; and side effects. Results: Some degree of sedation was observed after oral administration ofketamine. No effects on any of the other investigated parameters were observed. Conclusion: Oral ketamine 0.5 or 1.0 mg/kg has no effect on secondary hyperalgesia or thermal or mechanical pain thresholds in human volunteers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:41:22