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Titolo:
Antidepressants self-poisoning and ICU admissions in a University Hospitalin the Netherlands
Autore:
Bosch, TM; van der Werf, TS; Uges, DRA; Ligtenberg, JJM; Fijen, JW; Tulleken, JE; Zijlstra, JG;
Indirizzi:
Univ Groningen Hosp, Dept Internal Med, Intens & Resp Care Unit ICB, NL-9713 EZ Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9713 EZ ningen, Netherlands Univ Groningen Hosp, Dept Pharm, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands Pharm, Groningen, Netherlands
Titolo Testata:
PHARMACY WORLD & SCIENCE
fascicolo: 3, volume: 22, anno: 2000,
pagine: 92 - 95
SICI:
0928-1231(200006)22:3<92:ASAIAI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRICYCLIC ANTIDEPRESSANTS; OVERDOSE; MORTALITY; DISEASE; DRUGS;
Keywords:
antidepressants; (auto-)intoxication; selective serotonin re-uptake inhibitors; self-poisoning; toxicity; tricyclic antidepressants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: van der Werf, TS Univ Groningen Hosp, Dept Internal Med, Intens & Resp Care Unit ICB, Oostersingel 59, NL-9713 EZ Groningen, Netherlands Univ Groningen Hosp Oostersingel 59 Groningen Netherlands NL-9713 EZ
Citazione:
T.M. Bosch et al., "Antidepressants self-poisoning and ICU admissions in a University Hospitalin the Netherlands", PHARM WORLD, 22(3), 2000, pp. 92-95

Abstract

Objectives: Many overdosed patients are admitted to an ICU. Antidepressants are frequently used. We examined clinical end-points of toxicity recordedduring admission to our ICU of all antidepressants used in overdose. Design: Single centre; retrospective analysis, 5 consecutive years (1994 -1998). Setting: Intensive and Respiratory Care Unit, Groningen University Hospital. Participants: 86 patients admitted to the ICU because of antidepressant self-poisoning - database of 258 consecutively admitted patients with (auto-)intoxication. Results: Significantly more patients were intoxicated with TCAs (65) compared with SSRIs (20; p < 0.05), despite the fact that the number of prescriptions of antidepressants in the community was greater for SSRIs than for TCAs. Patients intoxicated with TCAs needed significantly more often trachealintubation (27/65 vs 7/20; p < 0.05), and these individuals had also significantly more often tachycardia (14 vs. 3) and QRS-complex widening (19 vs.1), compared to those with non-TCA antidepressant intoxication (p < 0.05). Conclusions: TCA self-poisoning has remained the predominant cause of morbidity among patients with auto-intoxication admitted to our ICU in the previous years. The data from this ICU-population confirm previous evidence that SSRIs are safer in overdose than TCAs. This finding was not explained by more prescriptions in the community of TCAs compared with SSRIs. Physiciansshould be more reluctant in prescribing TCAs to depressed patients in whomthe risk of self-poisoning is difficult to assess.

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Documento generato il 05/04/20 alle ore 09:18:14