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Titolo:
N-methyl-D-aspartic acid- and metaphit-induced audiogenic seizures in rat model of seizures
Autore:
Stanojlovic, O; Zivanovic, D; Susic, V;
Indirizzi:
Univ Belgrade, Sch Med, Dept Physiol, YU-11000 Belgrade, Yugoslavia Univ Belgrade Belgrade Yugoslavia YU-11000 YU-11000 Belgrade, Yugoslavia
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 3, volume: 42, anno: 2000,
pagine: 247 - 253
SICI:
1043-6618(200009)42:3<247:NAAMAS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENCYCLIDINE-LIKE DRUGS; ANTICONVULSANT ACTION; MICE; NMDA; ANTAGONISM; SUSCEPTIBILITY; RECEPTORS; NUCLEUS; KAINATE; SITE;
Keywords:
induced epilepsy; metaphit; NMDA; audiogenic seizures; animal; model of seizures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Stanojlovic, O Univ Belgrade, Sch Med, Dept Physiol, Karnegijeva 4, YU-11000 Belgrade, Yugoslavia Univ Belgrade Karnegijeva 4 Belgrade Yugoslavia YU-11000 a
Citazione:
O. Stanojlovic et al., "N-methyl-D-aspartic acid- and metaphit-induced audiogenic seizures in rat model of seizures", PHARMAC RES, 42(3), 2000, pp. 247-253

Abstract

The effects of NMDA (N-methyl-D-aspartic acid) on metaphit(1-[1(3-isothiocyanatophenyl)-cyclohexyl]piperidine)-induced audiogenic seizures in adult male Wistar albino rats were studied with the aim of developing a suitable animal model of seizures. The animals were divided into four experimental groups: 1, saline control; 2, metaphit-injected; 3, metaphit + NMDA administered and 4, NMDA-treated. Upon the treatment, the rats were exposed to sound stimulation (100 +/- 3 dB, for 60 s) at hourly intervals and the incidence and severity (running, clonus and tonus) of seizures were analysed. In group 3, only the animals which did not exhibit any metaphit-induced audiogenic seizures over 8 h weregiven a subconvulsive NMDA dose after the eigth audiogenic testing. For EEG recordings, three gold-plated screws were implanted into the rat skull. In most animals, metaphit led to EEC abnormalities and elicited epileptiform activity recorded as spikes, polyspikes and spike-wave complexes. Maximum incidence and severity of metaphit-induced convulsions occurred 8 h after injection (incidence 9/12), abating gradually until disappearing 30 hlater. NMDA alone provoked no seizure response but the initial signs characterized by isolated spike activity evolving into sporadic slow-wave complexes, thus representing a proconvulsive brain state, were observed. This compound led to stereotyped behaviour seen as asymmetric posture, loss of righting reflex and tonic hind limb extension lasting for 60-90 min. It also potentiated metaphit-induced audiogenic seizures, Potentiation of metaphit-related audiogenic seizures by NMDA was recorded in three out of 17 rats that had never displayed seizures in eight previous testings, with a maximum incidenceof eight out of 17 animals, 13-14 h after metaphit administration and seizures lasted for 10 h. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:18:03