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Titolo:
Effects of obesity and body fat distribution on lipids and lipoproteins innondiabetic American Indians: The Strong Heart Study
Autore:
Hu, DS; Hannah, J; Gray, RS; Jablonski, KA; Henderson, JA; Robbins, DC; Lee, ET; Welty, TK; Howard, BV;
Indirizzi:
MedStar Res Inst, Washington, DC 20010 USA MedStar Res Inst Washington DCUSA 20010 s Inst, Washington, DC 20010 USA
Titolo Testata:
OBESITY RESEARCH
fascicolo: 6, volume: 8, anno: 2000,
pagine: 411 - 421
SICI:
1071-7323(200009)8:6<411:EOOABF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR RISK-FACTORS; DEPENDENT DIABETES-MELLITUS; VISCERAL ADIPOSE-TISSUE; MALE-FEMALE DIFFERENCES; AGED 35-65 YEARS; ABDOMINAL OBESITY; SERUM-LIPIDS; ANTHROPOMETRIC MEASUREMENTS; PLASMA-LIPOPROTEINS; REGIONAL ADIPOSITY;
Keywords:
total obesity; central adiposity; lipid metabolism; Indians; North American;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Howard, BV MedStar Res Inst, 108 Irving St NW, Washington, DC 20010 USA MedStar Res Inst 108 Irving St NW Washington DC USA 20010 0 USA
Citazione:
D.S. Hu et al., "Effects of obesity and body fat distribution on lipids and lipoproteins innondiabetic American Indians: The Strong Heart Study", OBES RES, 8(6), 2000, pp. 411-421

Abstract

Objectives: To examine the relationship between obesity and lipoprotein profiles and compare the effects of total obesity and central adiposity on lipids/lipoproteins in American Indians. Research Methods and Procedures: Participants were 773 nondiabetic American Indian women and 739 men aged 45 to 74 years participating in the Strong Heart Study. Total obesity was estimated using body mass index (BMI). Central obesity was measured as waist circumference. Lipoprotein measures included triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein AI (apoAI), and apolipoproteinB (apoB). Partial and canonical correlation analyses were used to examine the associations between obesity and lipids/lipoproteins. Results: Women were more obese than men in Arizona (median BMI 32.1 vs. 29.2 kg/m(2)) and South Dakota and North Dakota (28.3 vs. 28.0 kg/m(2)), but there was no sex difference in waist circumference. Men had higher apoB andlower apoAI levels than did women. In women, when adjusted for center, gender, and age, BMI was significantly related to HDL cholesterol (r = -0.24, p < 0.001). There was a significant but weak relation with apoAI (r = -0.14, p < 0.001). Waist circumference was positively related to triglycerides (r = 0.14, p < 0.001) and negatively related to HDL cholesterol (r = -0.23, p < 0.001) and apoAI (r = -0.13, p < 0.001). In men, BMI was positively correlated with triglycerides (r = 0.30, p < 0.001) and negatively correlated with HDL cholesterol (r = -0.35, p < 0.001) and apoAI (r = -0.23, p < 0.001). Triglycerides increased with waist circumference (r = 0.30, p < 0.001) and HDL cholesterol decreased with waist circumference (r = -0.36, p < 0.001). In both women and men there was an inverted U-shaped relationship between obesity and waist with LDL cholesterol and apoB. In canonical correlationanalysis, waist circumference received a greater weight (0.86) than did BMI (0.17) in women. However, the canonical weights were similar for waist (0.46) and BMI (0.56) in men. Only HDL cholesterol (-1.02) carried greater weight in women, whereas in men, triglycerides (0.50), and HDL cholesterol (-0.64) carried a large amount of weight. All the correlation coefficients between BMI, waist circumference, and the first canonical variable of lipids/lipoproteins or between the individual lipid/lipoprotein variables and the first canonical variable of obesity were smaller in women than in men. Triglycerides and HDL cholesterol showed clinically meaningful changes with BMIand waist circumference in men. All lipid/lipoprotein changes in women in relation to BMI and waist circumference were minimal. Discussion: The main lipoprotein abnormality related to obesity in American Indians was decreased HDL cholesterol, especially in men. Central adiposity was more associated with abnormal lipid/lipoprotein profiles than general obesity in women; both were equally important in men.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:22:46