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Titolo:
The selective dopamine D4 receptor antagonist, PNU-101387G, prevents stress-induced cognitive deficits in monkeys
Autore:
Arnsten, AFT; Murphy, B; Merchant, K;
Indirizzi:
Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Neurobiol Sect, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Dept Pharmacol, New Haven, CT 06520 USA Pharmacia & Upjohn Inc, Kalamazoo, MI 49001 USA Pharmacia & Upjohn Inc Kalamazoo MI USA 49001 nc, Kalamazoo, MI 49001 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 23, anno: 2000,
pagine: 405 - 410
SICI:
0893-133X(200010)23:4<405:TSDDRA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
WORKING-MEMORY PERFORMANCE; PREFRONTAL CORTEX; PSYCHOLOGICAL STRESS; LOCALIZATION; NEURONS; BRAIN; NOREPINEPHRINE; CLOZAPINE; TURNOVER; NOISE;
Keywords:
memory; prefrontal cortex; stress; dopamine; D4 receptors; FG7142K;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Arnsten, AFT Yale Univ, Sch Med, Neurobiol Sect, Box 208001, New Haven, CT06520 USA Yale Univ Box 208001 New Haven CT USA 06520 ven, CT 06520 USA
Citazione:
A.F.T. Arnsten et al., "The selective dopamine D4 receptor antagonist, PNU-101387G, prevents stress-induced cognitive deficits in monkeys", NEUROPSYCH, 23(4), 2000, pp. 405-410

Abstract

Stress exposure impairs the cognitive functioning of the prefrontal cortex(PFC). Previous research has examined the dopamine (DA) D1 receptor mechanisms underlying this response. The current study performed a preliminary examination of the role of D4 receptor mechanisms by determining whether the selective D4 receptor antagonist, PNU-101387G, could prevent stress-inducedworking memory deficits in monkeys. Animals were tested on the delayed response task following treatment with PNU-101387G (0 or 0.1-0.8 mg/kg, 60-minpretreatment), and the pharmacological stressor, FG7142 (0 or 0.2 mg/kg, 30-min pretreatment). FG7142 significantly impaired delayed response performance relative to vehicle; PNU-101387G pretreatment produced a dose-related reversal oft he FG7142 response PNU-101387G had no significant effects on its own, but there were trends toward improvement at low doses and impairment at higher doses. Further studies in a larger number of animals appear warranted. These preliminary findings suggest that D4 receptor mechanisms contribute to stress-induced cognitive dysfunction. (C) 2000 American College of Neuropsychopharmacology.

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Documento generato il 20/01/20 alle ore 16:16:33