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Titolo:
Mazindol treatment of negative symptoms
Autore:
Carpenter, WT; Breier, A; Buchanan, RW; Kirkpatrick, B; Shepard, P; Weiner, E;
Indirizzi:
Univ Maryland, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD 21228 USA Univ Maryland Baltimore MD USA 21228 pt Psychiat, Baltimore, MD 21228 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 23, anno: 2000,
pagine: 365 - 374
SICI:
0893-133X(200010)23:4<365:MTONS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT SYNDROME; EXTRACELLULAR DOPAMINE; PREFRONTAL CORTEX; CHRONIC-SCHIZOPHRENIA; DOUBLE-BLIND; NORADRENALINE CARRIER; UPTAKE INHIBITORS; NONDEFICIT FORMS; CONTROLLED TRIAL; AMPHETAMINE;
Keywords:
schizophrenia; mazindol; negative symptoms; clinical trial; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Carpenter, WT Univ Maryland, Maryland Psychiat Res Ctr, Dept Psychiat, POB21247, Baltimore, MD 21228 USA Univ Maryland POB 21247 Baltimore MD USA 21228 MD 21228 USA
Citazione:
W.T. Carpenter et al., "Mazindol treatment of negative symptoms", NEUROPSYCH, 23(4), 2000, pp. 365-374

Abstract

Hypodopaminergic and hyponoradrenergic pathophysiology may be a basis for primary and/or secondary negative symptoms in schizophrenia. The hypothesisthat enhanced neurotransmission in these systems would be therapeutic for negative symptoms was tested by comparing mazindol and placebo in a double-blind, cross-over design trial. Outcome following mazindol supplementation was comparable to placebo supplementation (F(1,30) = 0.9; p = .57). Resultsfor deficit and non-deficit schizophrenia subjects were similar, and were not affected by whether concurrent the antipsychotic drug treatment was clozapine, fluphenazine, or haloperidol. The efficacy hypothesis was not supported for either primary or secondary negative symptoms. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:59:03