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Titolo:
Genotype effects on neurodegeneration and neuroadaptation in monoaminergicneurotransmitter systems
Autore:
Heinz, A; Goldman, D;
Indirizzi:
Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, Mannheim, Germany Cent Inst Mental Hlth Mannheim Germany & Addict Med, Mannheim, Germany NIAAA, Bethesda, MD USA NIAAA Bethesda MD USANIAAA, Bethesda, MD USA
Titolo Testata:
NEUROCHEMISTRY INTERNATIONAL
fascicolo: 5-6, volume: 37, anno: 2000,
pagine: 425 - 432
SICI:
0197-0186(200011/12)37:5-6<425:GEONAN>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE TRANSPORTER GENE; RECEPTOR-BINDING CHARACTERISTICS; ALCOHOL-DEPENDENT PATIENTS; DRD2 VARIANT SER311CYS; FREELY MOVING RATS; I-123 BETA-CIT; SEROTONIN TRANSPORTER; ALLELIC ASSOCIATION; D2 RECEPTOR; IN-VIVO;
Keywords:
dopamine; serotonin; brain reward system; alcoholism; neurotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Heinz, A Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, Mannheim, Germany Cent Inst Mental Hlth Mannheim Germany Med, Mannheim, Germany
Citazione:
A. Heinz e D. Goldman, "Genotype effects on neurodegeneration and neuroadaptation in monoaminergicneurotransmitter systems", NEUROCHEM I, 37(5-6), 2000, pp. 425-432

Abstract

Neuroadaptation and neurodegeneration in central dopaminergic and serotonergic systems are central to vulnerability, process and consequences of addictive behavior. Serotonergic dysfunction has been associated with behavior disinhibition and negative mood states that may predispose to excessive alcohol intake, while alcohol-induced stimulation of dopaminergic neurotransmission may encode the reinforcing properties of alcohol consumption. Chronicalcohol intake induces neuroadaptive reductions in striatal dopamine transporter (DAT) and D2 receptor availability, which were reversible during early abstinence. A polymorphism of the DAT gene (SLC6A3) was associated with the in vivo transporter availability in the putamen of abstinent alcoholicsand control subjects. The same genotype was associated with severity of alcohol withdrawal symptoms, hypothetically due to interactions of genotype and alcohol-induced neuroadaptation. Reduction in raphe serotonin transporter (5-HTT) availability was observed in abstinent male alcoholics and it maybe the result of neurodegeneration rather than reversible neuroadaptation. Neurotoxic reduction in 5-HTT protein expression seems to be limited to homozygous carriers of a long, more transcriptionally active allele of a promoter repeat polymorphism of the 5-HTT gene (SCL6A4). This genotype was alsoassociated with a low level of acute unpleasant effects of alcohol consumption, a factor predisposing to excessive alcohol intake. The time course ofneuroadaptation and recovery of monoaminergic neurotransmission in alcoholintake and withdrawal imply that monoamine transporter genotype could profoundly influence alcohol-induced reinforcement and, perhaps, contribute to neurochemical changes which are long lasting or permanent. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:37:05