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Titolo:
CO-TRANSPLANTATION OF FETAL LATERAL GANGLIONIC EMINENCE AND VENTRAL MESENCEPHALON CAN AUGMENT FUNCTION AND DEVELOPMENT OF INTRASTRIATAL TRANSPLANTS
Autore:
COSTANTINI LC; SNYDERKELLER A;
Indirizzi:
HARVARD UNIV,MCLEAN HOSP,SCH MED,NEUROREGENERAT LAB,MRC 119,115 MILL ST BELMONT MA 02178 SUNY ALBANY,SCH PUBL HLTH,NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS& RES ALBANY NY 12201
Titolo Testata:
Experimental neurology
fascicolo: 1, volume: 145, anno: 1997,
pagine: 214 - 227
SICI:
0014-4886(1997)145:1<214:COFLGE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAFTED DOPAMINE NEURONS; INDUCED FOS EXPRESSION; NON-TARGET CELLS; STRIATAL GRAFTS; PARKINSONS-DISEASE; INVITRO MATURATION; NEUROTROPHIC FACTOR; NIGRAL GRAFTS; GROWTH-FACTOR; RICH GRAFTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
L.C. Costantini e A. Snyderkeller, "CO-TRANSPLANTATION OF FETAL LATERAL GANGLIONIC EMINENCE AND VENTRAL MESENCEPHALON CAN AUGMENT FUNCTION AND DEVELOPMENT OF INTRASTRIATAL TRANSPLANTS", Experimental neurology, 145(1), 1997, pp. 214-227

Abstract

Methods to increase the development and sustained function of embryonic mesencephalic dopamine cells after transplantation into dopamine (DA)-depleted striatum are currently under investigation, Elements that are crucial for the maturation and connectivity of neurons during normal development of the brain way also play a role in the development and integration of grafted embryonic tissue. Based on in vitro and in vivo observations of the enhancing effects of striatal tissue on nigral dopaminergic cell development and survival, we demonstrate that inclusion of embryonic striatal cells, specifically from the lateral ganglionic eminence (LGE), produces dopaminergic transplants with augmented functional effects. Rats neonatally DA-depleted and co-transplanted with embryonic nigral and LGE cells developed improved functional outcomewhen compared with animals receiving only nigral cells, and they required the transplantation of fewer nigral cells to produce a strong behavioral effect, Anatomically, the inclusion of LGE cells produced increased DA cell survival, a higher density of reinnervation into the DA-depleted host striatum, and patches of DA fibers within the co-transplants, There were also an increased number of host striatal cells whichinduced the immediate-early gene c-fos in co-transplanted animals compared to animals receiving nigral cells alone, indicating a higher degree of host-cell activation. The ability to enhance function, cell survival, reinnervation, and host activation with nigral-striatal co-transplants in the presence of fewer nigral cells supports the hypothesis of a trophic influence of striatal cells on nigral DA cells. (C) 1997 Academic Press.

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Documento generato il 15/07/20 alle ore 14:21:21