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Titolo:
Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism
Autore:
Ramos, JW; Hughes, PE; Renshaw, MW; Schwartz, MA; Formstecher, E; Chneiweiss, H; Ginsberg, MH;
Indirizzi:
Scripps Clin & Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA Coll France, INSERM, Chaire Neuropharmacol, U114, F-75231 Paris, France Coll France Paris France F-75231 opharmacol, U114, F-75231 Paris, France
Titolo Testata:
MOLECULAR BIOLOGY OF THE CELL
fascicolo: 9, volume: 11, anno: 2000,
pagine: 2863 - 2872
SICI:
1059-1524(200009)11:9<2863:DEDPPP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTEGRIN CYTOPLASMIC DOMAINS; NECROSIS-FACTOR RECEPTOR; R-RAS; INDUCED APOPTOSIS; BINDING; PATHWAY; GRB2; TRANSDUCTION; INTERACTS; GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Ramos, JW Scripps Clin & Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 lla, CA 92037 USA
Citazione:
J.W. Ramos et al., "Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism", MOL BIOL CE, 11(9), 2000, pp. 2863-2872

Abstract

PEA-15 is a small, death effector-domain (DED)-containing protein that wasrecently demonstrated to inhibit tumor necrosis factor-alpha-induced apoptosis and to reverse the inhibition of integrin activation due to H-Ras. This led us to investigate the involvement of PEA-15 in Ras signaling. Surprisingly, PEA-15 activates the extracellular signal receptor-activated kinase (ERK) mitogen-activated protein kinase pathway in a Ras-dependent manner. PEA-15 expression in Chinese hamster ovary cells resulted in an increased mitogen-activated protein kinase kinase and ERK activity. Furthermore; PEA-15expression leads to an increase in Pas guanosine 5'-triphosphate loading. PEA-15 bypasses the anchorage dependence of ERK activation. Finally, the effects of PEA-15 on integrin signaling are separate from those on ERK activation. Heretofore, all known DEDs functioned in the regulation of apoptosis.in contrast, the DED of PEA-15 is essential for its capacity to activate ERK. The ability of PEA-15 to simultaneously inhibit apoptosis and potentiate Ras-to-Erk signaling may be of importance for oncogenic processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 14:22:42