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Titolo:
EVIDENCE THAT A POSITIVE MODULATOR OF AMPA-TYPE GLUTAMATE RECEPTORS IMPROVES DELAYED RECALL IN AGED HUMANS
Autore:
LYNCH G; GRANGER R; AMBROSINGERSON J; DAVIS CM; KESSLER M; SCHEHR R;
Indirizzi:
CORTEX PHARMACEUT INC,15241 BARRANCA PKWY IRVINE CA 92718
Titolo Testata:
Experimental neurology
fascicolo: 1, volume: 145, anno: 1997,
pagine: 89 - 92
SICI:
0014-4886(1997)145:1<89:ETAPMO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; RESPONSES; DRUG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
G. Lynch et al., "EVIDENCE THAT A POSITIVE MODULATOR OF AMPA-TYPE GLUTAMATE RECEPTORS IMPROVES DELAYED RECALL IN AGED HUMANS", Experimental neurology, 145(1), 1997, pp. 89-92

Abstract

Elderly subjects (65-76 years) were tested for recall of nonsense syllables prior to and after oral administration of 1-(quinoxalin-6 ylcarbonyl)piperidine (CX516), a centrally active drug that enhances currents mediated by AMPA-type glutamate receptors. A significant and positive drug effect was found for delayed (5 min) recall at 75 min posttreatment; average scores for the highest dose group were more than twofold greater than for the placebo group. The drug had no evident influence on heart rate or self-assessment of several psychological variables. (C) 1997 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 15:56:42