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Titolo:
INDUCTION OF TUMOR-SUPPRESSOR P53 AND DNA FRAGMENTATION IN ORGANOTYPIC HIPPOCAMPAL CULTURES FOLLOWING EXCITOTOXIN TREATMENT
Autore:
SAKHI S; BRUCE A; SUN N; TOCCO G; BAUDRY M; SCHREIBER SS;
Indirizzi:
UNIV SO CALIF,SCH MED,DEPT NEUROL,2025 ZONAL AVE,MCH 142 LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT CELL & NEUROBIOL LOS ANGELES CA 90033 UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089
Titolo Testata:
Experimental neurology
fascicolo: 1, volume: 145, anno: 1997,
pagine: 81 - 88
SICI:
0014-4886(1997)145:1<81:IOTPAD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOPTOTIC CELL-DEATH; WILD-TYPE P53; RAT-BRAIN; PROTEIN; EXPRESSION; DAMAGE; ACTIVATION; ISCHEMIA; KAINATE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S. Sakhi et al., "INDUCTION OF TUMOR-SUPPRESSOR P53 AND DNA FRAGMENTATION IN ORGANOTYPIC HIPPOCAMPAL CULTURES FOLLOWING EXCITOTOXIN TREATMENT", Experimental neurology, 145(1), 1997, pp. 81-88

Abstract

The p53 tumor suppressor gene encodes a cell cycle regulatory proteinthat is induced by DNA damage and has been implicated in apoptosis. To investigate whether excitotoxic cell death due to kainic acid (KA) and cell death due to N-methyl-D-aspartate (NMDA) share similar molecular mechanisms, we studied p53 expression and DNA fragmentation in organotypic hippocampal slice cultures following excitotoxin treatment. Cellular analyses showed that both p53 induction and DNA fragmentation occurred only in injured neurons following exposure to either excitotoxin. The temporal profiles of these changes demonstrated that p53 induction preceded DNA fragmentation. The extent of regional alterations inp53 expression and DNA fragmentation correlated with drug-related toxicity (i.e., NMDA > KA). These results support the hypothesis that p53is a marker of neuronal death in the CNS and suggest the possibility that excitotoxin-mediated neuronal death may occur through a p53-dependent pathway. (C) 1997 Academic Press.

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Documento generato il 18/01/21 alle ore 16:09:40