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Titolo:
Fibrillin-rich microfibrils of the extracellular matrix: ultrastructure and assembly
Autore:
Sherratt, MJ; Wess, TJ; Baldock, C; Ashworth, JL; Purslow, PP; Shuttleworth, CA; Kielty, CM;
Indirizzi:
Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Univ Manchester, Dept Med, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Royal Vet & Agr Univ, DK-1958 Copenhagen, Denmark Royal Vet & Agr Univ Copenhagen Denmark DK-1958 1958 Copenhagen, Denmark Univ Stirling, Dept Biol & Mol Sci, Stirling FK9 4LA, Scotland Univ Stirling Stirling Scotland FK9 4LA Sci, Stirling FK9 4LA, Scotland
Titolo Testata:
MICRON
fascicolo: 2, volume: 32, anno: 2001,
pagine: 185 - 200
SICI:
0968-4328(200102)32:2<185:FMOTEM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSMISSION ELECTRON-MICROSCOPY; ELASTIN-ASSOCIATED MICROFIBRILS; CONNECTIVE-TISSUE MICROFIBRILS; MARFAN-SYNDROME; VI COLLAGEN; GLYCOPROTEIN-1 MAGP-1; CALCIUM DETERMINES; EXPRESSION; ORGANIZATION; MUTATIONS;
Keywords:
fibrillin; microfibrils; ultrastructure; supramolecular organisation; scanning transmission electron microscopy; transmission electron microscopy; environmental scanning electron microscopy; atomic force microscopy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Sherratt, MJ Univ Manchester, Sch Biol Sci, 2-205 Stopford Bldg, Manchester M13 9PT, Lancs, England Univ Manchester 2-205 Stopford Bldg Manchester Lancs England M13 9PT
Citazione:
M.J. Sherratt et al., "Fibrillin-rich microfibrils of the extracellular matrix: ultrastructure and assembly", MICRON, 32(2), 2001, pp. 185-200

Abstract

Fibrillin-rich microfibrils are a unique class of extensible connective tissue macromolecules. Their critical contribution to the establishment and maintenance of diverse extracellular matrices was underlined by the linkage of their principal structural component fibrillin to Marfan syndrome, a heritable connective tissue disorder with pleiotropic manifestations. Microscopy and preparative techniques have contributed substantially to the understanding of microfibril structure and function. The supramolecular organisation of microfibrillar assemblies in tissues has been examined by tissue sectioning and X-ray diffraction methods. Published findings are discussed and new information reported on the organisation of microfibrils in the ciliaryzonular fibrils by environmental scanning electron microscopy. This reviewsummarises microscopy and X-ray diffraction studies that are informing current understanding of the ultrastructure of fibrillin-rich microfibrils. (C) 2000 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:45:24