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Titolo:
Human herpesvirus 8 transmission from mother to child and between siblingsin an endemic population
Autore:
Plancoulaine, S; Abel, L; van Beveren, M; Tregouet, DA; Joubert, M; Tortevoye, P; de The, G; Gessain, A;
Indirizzi:
Fac Med Necker, Inst Pasteur, Unite Oncol Virale, Dept SIDA & Retrovirus,Lab Genet Humaine Malad In, F-75015 Paris, France Fac Med Necker Paris France F-75015 aine Malad In, F-75015 Paris, France Fac Med Necker, Inst Pasteur, CNRS,URA 1930, Lab Genet Humaine Malad Infect, F-75015 Paris, France Fac Med Necker Paris France F-75015 Malad Infect, F-75015 Paris, France Fac Med Necker, Inst Pasteur, INSERM,U436, Lab Genet Humaine Malad Infect,F-75015 Paris, France Fac Med Necker Paris France F-75015 e Malad Infect,F-75015 Paris, France Fac Med Necker, Inst Pasteur, Unite Epidemiol Virus Oncogenes, Lab Genet Humaine Malad Infect, F-75015 Paris, France Fac Med Necker Paris France F-75015 Malad Infect, F-75015 Paris, France INSERM, U525, Paris, France INSERM Paris FranceINSERM, U525, Paris, France
Titolo Testata:
LANCET
fascicolo: 9235, volume: 356, anno: 2000,
pagine: 1062 - 1065
SICI:
0140-6736(20000923)356:9235<1062:HH8TFM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SARCOMA-ASSOCIATED HERPESVIRUS; KAPOSIS-SARCOMA; ESTIMATING EQUATIONS; HUMAN-HERPESVIRUS-8 INFECTION; SEXUAL TRANSMISSION; HIGH SEROPREVALENCE; SEROLOGIC EVIDENCE; HOMOSEXUAL MEN; ODDS-RATIO; ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Gessain, A Fac Med Necker, Inst Pasteur, Unite Oncol Virale, Dept SIDA & Retrovirus,Lab Genet Humaine Malad In, 28 Rue Dr Roux, F-75015 Paris, FranceFac Med Necker 28 Rue Dr Roux Paris France F-75015 ris, France
Citazione:
S. Plancoulaine et al., "Human herpesvirus 8 transmission from mother to child and between siblingsin an endemic population", LANCET, 356(9235), 2000, pp. 1062-1065

Abstract

Background Transmission or human herpesvirus 8 (HHV-8), the aetiological agent of Kaposi's sarcoma, is known to occur during sex among homosexual men. However, other modes of HHV-8 transmission remain to be elucidated in endemic populations. Methods We did a population-based seroepidemiological survey in a village in French Guiana among 1337 individuals of African origin (age 2-91 years) who had reliable genealogical data. Plasma samples were taken and tested for HHV-8-specific IgG by immunofluorescence assay. Risk factors and familialcorrelations for HHV-8 seropositivity were modelled by logistic regressionanalysis by use of the estimating equations approach, which expresses familial dependences in terms of odds ratios. Familial odds ratios were also acquired by use of the distribution of all possible pairs of a given familiardependence. Findings The overall HHV-8 seroprevalence was 13.2% with no difference according to sex. HHV-8 seropositivity was strongly age;dependent: at 1.2% under 5 years, HHV-8 seroprevalence rose up to a plateau around 15% between 15and 40 years, and showed a seroprevalence of more than 27% in individuals older than 40 years. Strong familial aggregation in HHV-8 seroprevalence was found with high mother-child (odd ratio 2.8 [95% CI 1.6-5.0]) and sib-sib(3.8 [1.6-9.5]) correlations. By:contrast, no significant correlation between spouses (0.6 [0.2-1.9]) was seen. Interpretation This pattern of familiar aggregation, together with the variation of HHV-8 seroprevalence with age, indicate that, in endemic populations, HHV-8 transmission mainly occurs from mother to child and between siblings during childhood and adolescence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:12:57