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Titolo:
The amygdala modulates memory consolidation of fear-motivated inhibitory avoidance learning but not classical fear conditioning
Autore:
Wilensky, AE; Schafe, GE; LeDoux, JE;
Indirizzi:
NYU, Ctr Neural Sci, WM Keck Fdn Lab Neurobiol, New York, NY 10003 USA NYU New York NY USA 10003 Keck Fdn Lab Neurobiol, New York, NY 10003 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 18, volume: 20, anno: 2000,
pagine: 7059 - 7066
SICI:
0270-6474(20000915)20:18<7059:TAMMCO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE-INDUCED AMNESIA; BASOLATERAL AMYGDALA; ENTORHINAL CORTEX; PROTEIN-SYNTHESIS; PARIETAL CORTEX; LESIONS; RATS; HIPPOCAMPUS; RETENTION; MUSCIMOL;
Keywords:
muscimol; memory; acquisition; consolidation; amygdala; inhibitory avoidance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: LeDoux, JE NYU, Ctr Neural Sci, WM Keck Fdn Lab Neurobiol, 4 Washington Pl,Room 809, New York, NY 10003 USA NYU 4 Washington Pl,Room 809 New York NY USA 10003 NY 10003 USA
Citazione:
A.E. Wilensky et al., "The amygdala modulates memory consolidation of fear-motivated inhibitory avoidance learning but not classical fear conditioning", J NEUROSC, 20(18), 2000, pp. 7059-7066

Abstract

Although the lateral and basal nuclei of the amygdala are believed to be essential for the acquisition of Pavlovian fear conditioning, studies using post-training manipulations of the amygdala in the inhibitory avoidance learning paradigm have recently called this view into question. We used the GABA(A) agonist muscimol to functionally inactivate these nuclei immediately after single-trial Pavlovian fear conditioning or single-trial inhibitory avoidance learning. Immediate post-training infusions of muscimol had no effect on Pavlovian conditioning but produced a dose-dependent effect on inhibitory avoidance. However, pretraining infusions dose-dependently disrupted Pavlovian conditioning. These findings indicate that the amygdala plays an essential role in the acquisition of Pavlovian fear conditioning and contributes to the modulation of memory consolidation of inhibitory avoidance butnot of Pavlovian fear conditioning.

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Documento generato il 21/09/20 alle ore 04:53:35