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Titolo:
Memory consolidation of auditory Pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala
Autore:
Schafe, GE; LeDoux, JE;
Indirizzi:
NYU, Ctr Neural Sci, WM Keck Fdn Lab Neurobiol, New York, NY 10003 USA NYU New York NY USA 10003 Keck Fdn Lab Neurobiol, New York, NY 10003 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 18, volume: 20, anno: 2000,
pagine: NIL_5 - NIL_9
SICI:
0270-6474(20000915)20:18<NIL_5:MCOAPF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ELEMENT-BINDING PROTEIN; DEPENDENT LATE-PHASE; AREA CA1; LTP; PKA; CAMP; HIPPOCAMPUS; INDUCTION; NUCLEUS;
Keywords:
fear; amygdala; LTP; memory consolidation; cAMP; protein synthesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Schafe, GE NYU, Ctr Neural Sci, WM Keck Fdn Lab Neurobiol, 4 Washington Pl,Room 809, New York, NY 10003 USA NYU 4 Washington Pl,Room 809 New York NY USA 10003 NY 10003 USA
Citazione:
G.E. Schafe e J.E. LeDoux, "Memory consolidation of auditory Pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala", J NEUROSC, 20(18), 2000, pp. NIL_5-NIL_9

Abstract

Previous studies have shown that long-term potentiation (LTP) can be induced in the lateral nucleus of the amygdala (LA) after stimulation of centralauditory pathways and that auditory fear conditioning modifies neural activity in the LA in a manner similar to LTP. The present experiments examinedwhether intra-LA administration of inhibitors of protein synthesis or protein kinase A (PKA) activity, treatments that block LTP in hippocampus, interfere with memory consolidation of fear conditioning. In the first series of experiments, rats received a single conditioning trial followed immediately by intra-LA infusions of anisomycin (a protein synthesis inhibitor) or Rp-cAMPS (an inhibitor of PKA activity) and were tested 24 hr later. Resultsindicated that immediate post-training infusion of either drug dose-dependently impaired fear memory retention, whereas infusions 6 hr after conditioning had no effect. Additional experiments showed that anisomycin and Rp-cAMPS interfered with long-term memory (LTM), but not short-term memory (STM), of fear and that the effect on LTM was specific to memory consolidation processes rather than to deficits in sensory or performance processes. Findings suggest that the LA is essential for memory consolidation of auditory fear conditioning and that this process is PKA and protein-synthesis dependent.

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Documento generato il 25/09/20 alle ore 00:26:09