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Titolo:
Workshop II: "Neuroprotection" - the Lugano consensus
Autore:
Riederer, P; Brucke, T; Muller, T; Schwartz, A; Storch, A; Winner, B;
Indirizzi:
Univ Wurzburg, Clin & Policlin Psychiat & Psychotherapy, Wurzburg, GermanyUniv Wurzburg Wurzburg Germany chiat & Psychotherapy, Wurzburg, Germany
Titolo Testata:
JOURNAL OF NEUROLOGY
, volume: 247, anno: 2000, supplemento:, 4
pagine: 36 - 37
SICI:
0340-5354(200009)247:<36:WI"-TL>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE;
Keywords:
Parkinson's disease; neuroprotection; neurorescue;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
4
Recensione:
Indirizzi per estratti:
Indirizzo: Riederer, P Univ Wurzburg, Clin & Policlin Psychiat & Psychotherapy, Wurzburg, Germany Univ Wurzburg Wurzburg Germany hotherapy, Wurzburg, Germany
Citazione:
P. Riederer et al., "Workshop II: "Neuroprotection" - the Lugano consensus", J NEUROL, 247, 2000, pp. 36-37

Abstract

Consensus could be reached that there is overwhelming evidence of preclinical neuroprotection. However, the evidence of neuroprotection/neurorescue under clinical conditions is limited. Lessons from clinical trials designed to show neuroprotection (selegiline, amantadine, dopamine agonists) demonstrate that with the drugs available neuroprotection/neurorescue has to startas early as possible. A PET-controlled clinical trial with ropinirole shows that there seems to be a good chance for neuroprotection in the early phase of Parkinson's disease in patients treated from the very beginning of the disease while there is no such benefit in patients with a late start of aneuroprotective therapeutic strategy. Also long-term neuroprotection cannot be reached. Complicating factors to demonstrate clinical neuroprotection are discussed.

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Documento generato il 17/09/19 alle ore 23:11:10