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Titolo:
DYNAMIC EXPRESSION SUGGESTS MULTIPLE ROLES OF THE EPH FAMILY RECEPTORBRAIN-SPECIFIC KINASE (BSK) DURING MOUSE NEUROGENESIS
Autore:
ZHANG JH; PIMENTA AF; LEVITT P; ZHOU RP;
Indirizzi:
RUTGERS STATE UNIV,COLL PHARM,CANC RES LAB PISCATAWAY NJ 08854 RUTGERS STATE UNIV,COLL PHARM,CANC RES LAB PISCATAWAY NJ 08854 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT NEUROSCI & CELL BIOL PISCATAWAY NJ 08854
Titolo Testata:
Molecular brain research
fascicolo: 1-2, volume: 47, anno: 1997,
pagine: 202 - 214
SICI:
0169-328X(1997)47:1-2<202:DESMRO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASES; LIMBIC SYSTEM; SPINAL-CORD; IDENTIFICATION; RAT; ORGANIZATION; CONNECTIONS; CLONING; LIGANDS; ELF-1;
Keywords:
EPH FAMILY RECEPTOR; HYBRIDIZATION, IN SITU; NEUROGENESIS; LIMBIC SYSTEM; TOPOGRAPHIC PROJECTION; AXONAL GUIDANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Zhang et al., "DYNAMIC EXPRESSION SUGGESTS MULTIPLE ROLES OF THE EPH FAMILY RECEPTORBRAIN-SPECIFIC KINASE (BSK) DURING MOUSE NEUROGENESIS", Molecular brain research, 47(1-2), 1997, pp. 202-214

Abstract

The eph family ligands and receptors have been implicated in mediating topographic neuron-target interactions. We recently isolated Bsk, a new member of the eph family receptors, and showed that it is expressed primarily in the brain. To investigate the role of Bsk in the development of the nervous system, we examined the temporal and spatial patterns of Bsk expression using in situ hybridization. We report here that Bsk expression exhibits dynamic changes during embryogenesis. In early embryos, Bsk is widely transcribed in the nervous system, includingthe forebrain, midbrain, hindbrain and spinal cord. Bsk expression inthe midbrain, hindbrain and spinal cord, however, gradually decreaseswhile in the forebrain increases over time. By embryonic day 18, the most intense Bsk expression was found in the limbic system. High levels of the expression in the limbic system persisted throughout post-natal development and remained stable in the adult up to 24 month. The topography of Bsk expression is in the form of gradients in several regions of the brain, including the lateral septum, spinal cord, as well as the hippocampus. Selective expression was also observed in Purkinje cells. Our findings on the topography of Bsk expression provide support to potential roles of Bsk in topographic projection. Our analyses further suggest that there may be other novel functions of Bsk in early neurogenesis in addition to potential roles in topographic mapping. (C) 1997 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:38:34