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Titolo:
Effects of multiple acute morphine exposures on feline immunodeficiency virus disease progression
Autore:
Barr, MC; Billaud, JN; Selway, DR; Huitron-Resendiz, S; Osborn, KG; Henriksen, SJ; Phillips, TR;
Indirizzi:
Vaccine Res Inst San Diego, San Diego, CA 92121 USA Vaccine Res Inst San Diego San Diego CA USA 92121 San Diego, CA 92121 USA Scripps Clin & Res Inst, Dept Neuropharmacol, La Jolla, CA USA Scripps Clin & Res Inst La Jolla CA USA Neuropharmacol, La Jolla, CA USA Scripps Clin & Res Inst, Dept Anim Resources, La Jolla, CA USA Scripps Clin & Res Inst La Jolla CA USA Anim Resources, La Jolla, CA USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 3, volume: 182, anno: 2000,
pagine: 725 - 732
SICI:
0022-1899(200009)182:3<725:EOMAME>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INJECTING DRUG-USERS; HIV-INFECTION; IN-VIVO; PRECIPITATED WITHDRAWAL; NEURONAL INJURY; HOMOSEXUAL MEN; CELL-CULTURES; FIV-PPR; BRAIN; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, TR Vaccine Res Inst San Diego, 3030 Sci Pk Rd, San Diego, CA 92121 USA Vaccine Res Inst San Diego 3030 Sci Pk Rd San Diego CA USA 92121
Citazione:
M.C. Barr et al., "Effects of multiple acute morphine exposures on feline immunodeficiency virus disease progression", J INFEC DIS, 182(3), 2000, pp. 725-732

Abstract

Drug abuse is a common method of human immunodeficiency virus type 1 transmission, but the role of opiates on lentivirus disease progression is not well understood. The feline immunodeficiency virus (FIV)/cat system was usedto model the weekend opiate abuser: the nondependent, nonaddicted, and nontolerant person. Sixteen cats were placed into 4 groups: FIV only, morphineonly, morphine/FIV, and controls. Multiple acute morphine exposure did notincrease the severity of early lentivirus infection. On the contrary, it delayed or moderated the FIV-induced disease progression. Although the animals were exposed to only 1 injection of morphine per day for 2 consecutive days per week, the morphine-treated FIV-infected animals had a delayed onsetof the FIV-induced lymphadenopathy, did not develop or had a significant delay in the FIV-induced effects on brain stem auditory evoked potentials, and demonstrated a trend toward decreased virus load.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:30:41