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Titolo:
Genetic epidemiology of hepatitis C virus throughout Egypt
Autore:
Ray, SC; Arthur, RR; Carella, A; Bukh, J; Thomas, DL;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 ect Dis, Baltimore, MD 21205USA NIAID, Hepatitis Viruses Sect, NIH, Bethesda, MD 20892 USA NIAID BethesdaMD USA 20892 tis Viruses Sect, NIH, Bethesda, MD 20892 USA WHO, CH-1211 Geneva, Switzerland WHO Geneva Switzerland CH-1211WHO, CH-1211 Geneva, Switzerland
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 3, volume: 182, anno: 2000,
pagine: 698 - 707
SICI:
0022-1899(200009)182:3<698:GEOHCV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC LIVER-DISEASE; ENTIRE NUCLEOTIDE-SEQUENCE; 5' NONCODING REGION; NON-B HEPATITIS; BLOOD-DONORS; PHYLOGENETIC ANALYSIS; PREDOMINANT GENOTYPE; ADDITIONAL SUBTYPES; HIGH SEROPREVALENCE; VIRAL GENOTYPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Ray, SC Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, 720 RutlandAve,Ross 1159, Baltimore, MD 21205 USA Johns Hopkins Univ 720 Rutland Ave,Ross 1159 Baltimore MD USA 21205
Citazione:
S.C. Ray et al., "Genetic epidemiology of hepatitis C virus throughout Egypt", J INFEC DIS, 182(3), 2000, pp. 698-707

Abstract

Hepatitis C virus (HCV) infection is a major health problem in Egypt, where the seroprevalence is 10-20-fold higher than that in the United States. To characterize the HCV genotype distribution and concordance of genotype assessments on the basis of multiple genomic regions, specimens were obtainedfrom blood donors in 15 geographically diverse governorates throughout Egypt. The 5' noncoding, core/E1, and NS5B regions were amplified by reverse transcription-polymerase chain reaction and analyzed by both restriction fragment length polymorphism (RFLP) and phylogenetic tree construction. For the 5' noncoding region, 122 (64%) of 190 specimens were amplified and analyzed by RFLP: 111 (91%) were genotype 4, 1 (1%) was genotype 1a, 1 (1%) was genotype 1b, and 9 (7%) could not be typed. Phylogenetic analyses of the core/E1 and NS5B regions confirmed the genotype 4 preponderance and revealed evidence of 3 new subtypes, Analysis of genetic distance between isolates was consistent with the introduction of multiple virus strains 75-140 years ago, and no clustering was detected within geographic regions, suggesting widespread dispersion at some time since then.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:44:58