Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Salivary EGF levels reduced in diabetic patients
Autore:
Oxford, GE; Tayari, L; Barfoot, MD; Peck, AB; Tanaka, Y; Humphreys-Beher, MG;
Indirizzi:
Univ Florida, Coll Dent, Dept Oral Biol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 ral Biol, Gainesville, FL 32610 USA
Titolo Testata:
JOURNAL OF DIABETES AND ITS COMPLICATIONS
fascicolo: 3, volume: 14, anno: 2000,
pagine: 140 - 145
SICI:
1056-8727(200005/06)14:3<140:SELRID>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; GASTROINTESTINAL ABSORPTION; SUBMANDIBULAR-GLAND; PAROTID-GLAND; MICE; RATS; DISEASE; MOUSE; ALPHA; EXPRESSION;
Keywords:
wound healing; EGF; saliva; diabetes; complications;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Oxford, GE Univ Florida, Coll Dent, Dept Oral Biol, JHMHSC Box 100424, Gainesville, FL 32610 USA Univ Florida JHMHSC Box 100424 Gainesville FL USA 32610 610 USA
Citazione:
G.E. Oxford et al., "Salivary EGF levels reduced in diabetic patients", J DIABET C, 14(3), 2000, pp. 140-145

Abstract

Oral problems such as periodontitis are recognized major complications associated with diabetes. Salivary derived growth factors, including epidermalgrowth factor (EGF), are thought to play a role in helping maintain levelsof oral health, promoting wound healing, and maintaining mucosal integrity. In the present study, salivary levels of EGF in diabetic vs. healthy control patients was evaluated. Twenty-one diabetic patients participated in this study. Age, race, sex and smoking histories were matched with 21 systematically healthy nondiabetic patients. Three milliliters of unstimulated resting whole saliva was collected from each patient at 6 h intervals up to 42h and whole saliva protein concentrations were determined for each sample. EGF concentrations for each sample were quantitated spectrophometrically utilizing an immunoassay. Diabetic patients had greater salivary protein concentrations over 42 h of collection with a mean of 1.502 +/- 0.09 vs. 1.242+/- 0.05 mg/ml for healthy control patients. The EGF concentration was significantly lower (p < 0.05) for the diabetic patients compared to control patients, whether expressed relative to 1 mi volume of saliva (873.43 +/- 106.5 vs. 1101.09 +/- 116.8 pg/ml) or 1 mg whole saliva protein (629.18 +/- 92.6 vs. 931.20 +/- 124.6 pg/mg saliva protein). This study suggests that reduced levels of salivary EGF in diabetic patients may contribute to the development of oral and systemic complications of diabetes, which may have future clinical applications. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:03:03