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Titolo:
Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: Roles in the adhesion and migration of putative endocrine progenitor cells
Autore:
Cirulli, V; Beattie, GM; Klier, G; Ellisman, M; Ricordi, C; Quaranta, V; Frasier, F; Ishii, JK; Hayek, A; Salomon, DR;
Indirizzi:
Scripps Clin & Res Fdn, Res Inst, Dept Mol & Expt Med, MEM55, La Jolla, CA92037 USA Scripps Clin & Res Fdn La Jolla CA USA 92037 MEM55, La Jolla, CA92037 USA Scripps Clin & Res Fdn, Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Clin & Res Fdn La Jolla CA USA 92037 Biol, La Jolla, CA 92037 USA Univ Calif San Diego, Natl Ctr Microscopy & Imaging Res, La Jolla, CA 92037 USA Univ Calif San Diego La Jolla CA USA 92037 ng Res, La Jolla, CA 92037 USA Univ Calif San Diego, Dept Pediat, Whittier Inst Diabet, Islet Res Lab, LaJolla, CA 92037 USA Univ Calif San Diego La Jolla CA USA 92037 Res Lab, LaJolla, CA 92037 USA Univ Miami, Sch Med, Diabet Res Inst, Miami, FL 33136 USA Univ Miami Miami FL USA 33136 h Med, Diabet Res Inst, Miami, FL 33136 USA
Titolo Testata:
JOURNAL OF CELL BIOLOGY
fascicolo: 6, volume: 150, anno: 2000,
pagine: 1445 - 1459
SICI:
0021-9525(20000918)150:6<1445:EAFOAA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-FETAL PANCREAS; HEPATOCYTE GROWTH-FACTOR; PLASMA-MEMBRANE DOMAINS; EXTRACELLULAR-MATRIX; ISLET CELLS; ALPHA-3-BETA-1 INTEGRIN; BASEMENT-MEMBRANE; NUDE-MICE; DIFFERENTIATION; INVOLUTION;
Keywords:
pancreatic islets; endocrine progenitors; alpha(v)beta(3); integrins; cell migration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Salomon, DR Scripps Clin & Res Fdn, Res Inst, Dept Mol & Expt Med, MEM55, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Fdn 10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
V. Cirulli et al., "Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: Roles in the adhesion and migration of putative endocrine progenitor cells", J CELL BIOL, 150(6), 2000, pp. 1445-1459

Abstract

Cell-cell and cell-matrix, interactions play a critical role in tissue morphogenesis and in homeostasis of adult tissues. The integrin family of adhesion receptors regulates cellular interactions with the extracellular matrix, which provides three-dimensional information for tissue organization. Itis currently thought that pancreatic islet cells develop from undifferentiated progenitors residing within the ductal epithelium of the fetal pancreas. This process involves cell budding from the duct, migration into the surrounding mesenchyme, differentiation, and clustering into the highly organized islet of Langerhans. Here we report that alpha(v)beta(3) and alpha(v)beta(5), two integrins known to coordinate epithelial cell adhesion and movement, are expressed in pancreatic ductal cells and clusters of undifferentiated cells emerging from the ductal epithelium. We show that expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins are developmentally regulated during pancreatic islet ontogeny, and mediate adhesion and migration of putative endocrine progenitor cells both in vitro and in vivo in a model of pancreatic islet development. Moreover, we demonstrate the expression of fibronectin and collagen IV in the basal membrane of pancreatic ducts and of cell clusters budding from the ductal epithelium. Conversely, expression of vitronectin marks a population of epithelial cells adjacent to,or emerging from, pancreatic ducts. Thus, these data provide the first evidence for the contribution of integrins alpha(v)beta(3) and alpha(v)beta(5)and their ligands to morphogenetic events in the human endocrine pancreas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:39:23