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Titolo:
Biocompatibility and performance in vitro of a hemostatic gelatin sponge
Autore:
Cenni, E; Ciapetti, G; Stea, S; Corradini, A; Carozzi, F;
Indirizzi:
Ist Ortoped Rizzoli, Dipartimento Putti, Bologna, Italy Ist Ortoped Rizzoli Bologna Italy i, Dipartimento Putti, Bologna, Italy Mascia Brunelli SPA, Milan, Italy Mascia Brunelli SPA Milan ItalyMascia Brunelli SPA, Milan, Italy
Titolo Testata:
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
fascicolo: 7, volume: 11, anno: 2000,
pagine: 685 - 699
SICI:
0920-5063(2000)11:7<685:BAPIVO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-THROMBOGLOBULIN; BLOOD COMPATIBILITY; MUTAGENICITY TEST; RELEASE REACTION; PLATELET; EMBOLIZATION; CARCINOGENS; ACTIVATION; POLYMER; AGENTS;
Keywords:
hemostatic sponge; gelatin; cytotoxicity; genotoxicity; platelet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Cenni, E Ist Ortoped Rizzoli, Dipartimento Putti, Bologna, Italy Ist Ortoped Rizzoli Bologna Italy imento Putti, Bologna, Italy
Citazione:
E. Cenni et al., "Biocompatibility and performance in vitro of a hemostatic gelatin sponge", J BIOM SC P, 11(7), 2000, pp. 685-699

Abstract

The biocompatibility of a hemostatic gelatin sponge (Cutanplast Standard) was evaluated in vitro. Cytotoxicity was assessed by neutral red uptake andamido black staining tests; genotoxicity was assayed using the Ames test, Sister Chromatides Exchanges (SCE) and chromosomal aberrations. The abilityof the hemostatic gelatin sponge to induce platelet adhesion and release reaction was also determined. The undiluted extract of the test material wasfound to be cytotoxic, but cell viability was not affected by 1:2 and 1:10diluted extract. The same extract was found to be non-genotoxic using the three assays for genotoxicity. A significant decrease of platelet number, as well as a significant release of platelet factor 4 was found to be causedby the solid material. In conclusion, Cutanplast Standard is neither cytotoxic nor genotoxic, while inducing platelet adhesion and release reaction when challenged with blood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:01:15