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Titolo:
Papin - A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neuralplakophilin-related armadillo repeat protein/delta-catenin and p0071
Autore:
Deguchi, M; Iizuka, T; Hata, Y; Nishimura, W; Hirao, K; Yao, I; Kawabe, H; Takai, Y;
Indirizzi:
Osaka Univ, Grad Sch Med, Fac Med, Dept Mol Biol & Biochem, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Biochem, Suita, Osaka 5650871, Japan JCR Pharmaceut Co Ltd, Japan Sci & Technol Corp, Exploratory Res Adv Technol, Takai Biotimer Project, Kobe, Hyogo 6512241, Japan JCR Pharmaceut Co Ltd Kobe Hyogo Japan 6512241 Kobe, Hyogo 6512241, Japan Tokyo Med & Dent Univ, Dept Med Biochem, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 38, volume: 275, anno: 2000,
pagine: 29875 - 29880
SICI:
0021-9258(20000922)275:38<29875:P-ANMP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR PROTEIN; JUNCTION-ASSOCIATED PROTEIN; TYROSINE KINASE SUBSTRATE; DOMAIN-CONTAINING PROTEIN; BETA-CATENIN; POSTSYNAPTIC DENSITY; DESMOSOMAL PLAQUE; MULTIGENE FAMILY; BAND-6 PROTEIN; DELTA-CATENIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Takai, Y Osaka Univ, Grad Sch Med, Fac Med, Dept Mol Biol & Biochem, 2-2 Yamadaoka,Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
M. Deguchi et al., "Papin - A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neuralplakophilin-related armadillo repeat protein/delta-catenin and p0071", J BIOL CHEM, 275(38), 2000, pp. 29875-29880

Abstract

A neural plakophilin-related armadillo repeat protein (NPRAP)/delta-catenin interacts with one of Alzheimer disease-related gene products, presenilin1. We have previously reported the interaction of NPRAP/delta-catenin withsynaptic scaffolding molecule, which is involved in the assembly of synaptic components. NPRAP/delta-catenin also interacts with E-cadherin and beta-catenin and is implicated in the organization of cell-cell junctions. p0071, a ubiquitous isoform of NPRAP/delta-catenin, is localized at desmosomes in HeLa and A431 cells and at adherens junctions in Madin-Darby bovine kidney cells. We have identified here a novel protein interacting with NPRAP/ delta-catenin and p0071 and named this protein plakophilin-related armadillo repeat protein-interacting PSD-95/ Dlg-A/ZO-1 (PDZ) protein (PAPIN). PAPIN has six PDZ domains and binds to NPRAP/delta-catenin and p0071 via the second PDZ domain. PAPIN and p0071 are ubiquitously expressed in various tissues and are localized at cell-cell junctions in normal rat kidney cells and bronchial epithelial cells. PAPIN may be a scaffolding protein connecting components of epithelial junctions with p0071.

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Documento generato il 15/07/20 alle ore 13:52:28