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Titolo:
Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells
Autore:
Masuda, A; Matsuguchi, T; Yamaki, K; Hayakawa, T; Kubo, M; LaRochelle, WJ; Yoshikai, Y;
Indirizzi:
Nagoya Univ, Sch Med, Dis Mechanism & Control Res Inst, Lab Host Def & Germfree Life,Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya AichiJapan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ, Sch Med, Dis Mechanism & Control Res Inst, Dept Internal Med 2,Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Sci Univ Tokyo, Res Inst Biol Sci, Div Immunobiol, Tokyo 2780022, Japan Sci Univ Tokyo Tokyo Japan 2780022 Div Immunobiol, Tokyo 2780022, Japan NCI, Cellular & Mol Biol Lab, NIH, Bethesda, MD 20892 USA NCI Bethesda MDUSA 20892 lar & Mol Biol Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 38, volume: 275, anno: 2000,
pagine: 29331 - 29337
SICI:
0021-9258(20000922)275:38<29331:IIRTPO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN T-CELLS; BETA-CHAIN; IL-4 PRODUCTION; GROWTH-FACTOR; GM-CSF; RECEPTOR; CYTOKINE; LYMPHOKINE; DIFFERENTIATION; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuguchi, T Nagoya Univ, Sch Med, Dis Mechanism & Control Res Inst, Lab Host Def & Germfree Life,Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan Nagoya Univ 65 Tsurumai Cho Nagoya Aichi Japan 4668550 Japan
Citazione:
A. Masuda et al., "Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells", J BIOL CHEM, 275(38), 2000, pp. 29331-29337

Abstract

Interleukin (IL)-4 plays an important role in the differentiation of naiveT helper (Th) cells into Th2. Mast cells can produce a significant amount of IL-4 and have been proposed to play a major role in the induction of Th2responses. Recently, it has been reported that mast cells have a distinct IL-15 receptor system different from that of T or natural killer cells. In the present study, we demonstrated that IL-15 induced IL-4 production from a mouse mast cell line, MC/9, and bone marrow-derived mast cells. IL-4 mRNAexpression was increased by IL-15, suggesting that IL-15 promotes IL-4 expression at the transcriptional Level. In these mast cells, signal transducer and activator of transcription (STAT) 6 were rapidly tyrosine-phosphorylated in response to IL-15. In MC/9 cells, the expression of a C-terminally truncated dominant negative form of STAT6 significantly suppressed the IL-4 mRNA up-regulation by IL-15, suggesting that STAT6 activation is essential for the IL-15-mediated IL-4 production. Additionally, tyrosine phosphorylation of Tyk2 was rapidly increased by IL-15 treatment in this cell line. Altogether, our results suggest that IL-15 plays an important role in stimulating early IL-4 production in mast cells that may be responsible for the initiation of Th2 response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 00:41:31