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Titolo:
Differences between women and men in adverse events and CD4(+) responses to nucleoside analogue therapy for HIV infection
Autore:
Currier, JS; Spino, C; Grimes, J; Wofsy, CB; Katzenstein, DA; Hughes, MD; Hammer, SM; Cotton, DJ;
Indirizzi:
Univ Calif Los Angeles, Ctr Clin AIDS Res & Educ, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 niv, Sch Publ Hlth, Boston, MA 02115 USA Univ Calif San Francisco, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Stanford Univ, Palo Alto, CA 94304 USA Stanford Univ Palo Alto CA USA 94304 anford Univ, Palo Alto, CA 94304 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Boston Univ, Boston, MA 02215 USA Boston Univ Boston MA USA 02215Boston Univ, Boston, MA 02215 USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 4, volume: 24, anno: 2000,
pagine: 316 - 324
SICI:
1525-4135(20000801)24:4<316:DBWAMI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS INFECTION; PLACEBO-CONTROLLED TRIAL; CUBIC MILLIMETER; CELL COUNTS; GENDER DIFFERENCES; DOUBLE-BLIND; ZIDOVUDINE; AIDS; PHARMACOKINETICS; DIDANOSINE;
Keywords:
nucleoside analogues; adverse events; gender differences; CD4(+) response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Currier, JS Univ Calif Los Angeles, Ctr Clin AIDS Res & Educ, 10833 Le Conte Ave,Room BH-412-CHS, Los Angeles, CA 90095 USA Univ Calif Los Angeles 10833 Le Conte Ave,Room BH-412-CHS Los Angeles CA USA 90095
Citazione:
J.S. Currier et al., "Differences between women and men in adverse events and CD4(+) responses to nucleoside analogue therapy for HIV infection", J ACQ IMM D, 24(4), 2000, pp. 316-324

Abstract

Objective: To prospectively examine differences in baseline characteristics and study outcomes between HIV-infected women and men during a clinical trial of nucleoside analogue therapy. Methods: ACTG 175 randomized HIV-infected patients with CD4(+) counts between 200 and 500 cells/mm(3) to one of four nucleoside analogue regimens: zidovudine (ZDV), didanosine (ddI), ZDV + ddI, or ZDV + zalcitabine (ddC). Differences in time to first dose modification, voluntary withdrawal, development of toxicity and symptomatology, and AIDS progression were compared by gender. Results: The study included 438 women and 2029 men. Baseline values of HIVRNA plasma concentrations were significantly lower for women (0.3 log(10))than men in a subset of patients in whom assays were taken and this difference persisted after adjustment for CD4(+) count. Women reported reducing dosage and discontinue ddI-containing regimens more frequently than men did;adjustment for weight did not completely explain this difference, Women were at lower risk than men for progression to a study endpoint (19% of womenversus 24% of men; p < .0001). Among these antiretroviral-naive study subjects receiving ZDV, men were four times more likely to progress to a study endpoint than women. Conclusions: Differences in pretreatment characteristics and on study experiences were demonstrated between women and men enrolled in this clinical trial. The suggestion of a gender difference in response to ZDV monotherapy by antiretroviral-naive study subjects and the lower baseline values for HIV RNA in women compared with those in men provides evidence for gender differences in the relationship between virus replication, CD4(+) decline, and responses to nucleoside analogue therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:39:59