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Titolo:
Development of acute psychotic disorders and HIV-1 infection
Autore:
De Ronchi, D; Faranca, I; Forti, P; Ravaglia, G; Borderi, M; Manfredi, R; Volterra, V;
Indirizzi:
Univ Bologna, Sch Med, Inst Psychiat, I-40123 Bologna, Italy Univ BolognaBologna Italy I-40123 Inst Psychiat, I-40123 Bologna, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
fascicolo: 2, volume: 30, anno: 2000,
pagine: 173 - 183
SICI:
0091-2174(2000)30:2<173:DOAPDA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIDS; SCHIZOPHRENIA; DISEASE;
Keywords:
HIV infection; acquired immunodeficiency syndrome; AIDS dementia complex; schizophrenia and disorders with psychotic features; antiviral agents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: De Ronchi, D Univ Bologna, Sch Med, Inst Psychiat, Viale Carlo Pepoli 5, I-40123 Bologna, Italy Univ Bologna Viale Carlo Pepoli 5 Bologna Italy I-40123 taly
Citazione:
D. De Ronchi et al., "Development of acute psychotic disorders and HIV-1 infection", INT J PSY M, 30(2), 2000, pp. 173-183

Abstract

Objective; To gain more understanding about the relationship between humanimmunodeficiency virus type 1 (HIV-1) infection and new-onset psychosis, we compared clinical and immunological findings, psychiatric symptoms, global cognitive performance and, when available, computerized tomography (CT) findings between HIV-1-seropositive patients with new-onset psychosis and well-matched nonpsychotic HIV-1-seropositives. Methods: Two groups of subjects: HIV-1-seropositives with new-onset psychosis (n = 12) and HIV-1-seropositives without psychosis (n = 15) were recruited through outpatient departments. Organic Delusional Syndrome and Organic Hallucinosis were clinically diagnosed using DSM-III-R diagnostic criteria. Of the baseline participants,twenty-two participated in the two-year follow-up examination. Results: The prevalence of new-onset psychosis in HIV-1-infected subjects was 3.7 per 100 (95% C.I. = 1.6-5.7). HIV-1-seropositive persons with new-onset psychosis had more frequently a positive past psychiatric history, no antiretroviral therapy, and a lower global cognitive performance than did the nonpsychotic HIV-1-seropositives. CT was positive, showing generalized brain atrophy, in three out of nine patients. Remission of psychotic symptoms was observed only in two HIV-1-seropositive persons with new-onset psychosis. Death occurred in two psychotic HIV-1-seropositives with simple loosely held delusions. Autopsy results showed that cortical sulci and ventricle size were graded as with moderate/severe enlargement. Conclusions: New-onset psychosis in HIV infected patients could raise considerable problems in deciding whether a presentation is organic or functional. An interaction of the disease or of psychologically "having" the disease with the presence of a psychoticreaction should also be considered. Interestingly, a protective effect of antiretroviral therapy for new-onset psychosis is suggested.

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Documento generato il 21/01/20 alle ore 01:36:05