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Titolo:
Heregulin regulates the actin cytoskeleton and promotes invasive properties in breast cancer cell lines
Autore:
Hijazi, MM; Thompson, EW; Tang, C; Coopman, P; Torri, JA; Yang, DJ; Mueller, SC; Lupu, R;
Indirizzi:
Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ley Lab, Berkeley, CA 94720 USA Georgetown Univ, Med Ctr, Vincent T Lombardi Canc Res Ctr, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 Res Ctr, Washington, DC 20007 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 4, volume: 17, anno: 2000,
pagine: 629 - 641
SICI:
1019-6439(200010)17:4<629:HRTACA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; NEU DIFFERENTIATION FACTOR; MAMMARY EPITHELIAL-CELLS; ESTROGEN-RECEPTOR; PHOSPHATIDYLINOSITOL 3-KINASE; TYROSINE PHOSPHORYLATION; BASEMENT-MEMBRANE; ONCOGENE PRODUCT; EGF RECEPTOR; TUMOR CELLS;
Keywords:
heregulin; erbB(2); growth; invasion; cell motility; actin cytoskeleton;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Lupu, R Univ Calif Berkeley, Lawrence Berkeley Lab, 1 Cyclotron Rd, Berkeley, CA 94720 USA Univ Calif Berkeley 1 Cyclotron Rd Berkeley CA USA 94720 94720 USA
Citazione:
M.M. Hijazi et al., "Heregulin regulates the actin cytoskeleton and promotes invasive properties in breast cancer cell lines", INT J ONCOL, 17(4), 2000, pp. 629-641

Abstract

The metastatic process requires changes in tumor cell adhesion properties,cell motility and remodeling of the extracellular matrix. The erbB(2) proto-oncogene is overexpressed in approximately 30% of breast cancers and is amajor prognostic parameter when present, in invasive disease. A ligand forthe erbB(2) receptor has not yet been identified but it can be activated by heterodimerization with heregulin (HRG)-stimulated erbB(3) and erbB(4) receptors. The HRGs are a family of polypeptide growth factors that have beenshown to play a role in embryogenesis, tumor formation, growth and differentiation of breast cancer cells. The erbB(3) and erbB(4) receptors are involved in transregulation of erbB(2) signaling. The work presented here suggests biological roles for HRG including regulation of the actin cytoskeletonand induction of motility and invasion in breast cancer cells. HRG-expressing breast cancer cell lines are characterized by low erbB receptor levels and a high invasive and metastatic index, while those which overexpress erbB(2) demonstrate minimal invasive potential in vitro and are non-tumorigenic in vivo. Treatment of the highly tumorigenic and metastatic HRG-expressing breast cancer cell line MDA-MB-231 with an HRG-neutralizing antibody significantly inhibited proliferation in culture and motility in the Boyden chamber assay. Addition of exogenous HRG to non-invasive erbB(2) overexpressing cells (SKBr-3) at low concentrations induced formation of pseudopodia, enhanced phagocytic activity and increased chemomigration and invasion in theBoyden chamber assay. The specificity of the chemomigration response to HRG is demonstrated by inhibition with the anti-HRG neutralizing antibody. These results suggest that either HRG can act as an autocrine or paracrine ligand to promote the invasive behavior of breast cancer cells ill vitro or thus may enhance the metastatic process in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:12:52