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Titolo:
Absence of RBM expression as a marker of intratubular (in situ) germ cell neoplasia of the testis
Autore:
Lifschitz-Mercer, B; Elliott, DJ; Leider-Trejo, L; Schreiber-Bramante, L; Hassner, A; Eisenthal, A; Maymon, BBS;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Inst Pathol, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 Pathol, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 al Med, IL-64239 Tel Aviv, Israel Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH4 2XU dlothian, Scotland
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 9, volume: 31, anno: 2000,
pagine: 1116 - 1120
SICI:
0046-8177(200009)31:9<1116:AOREAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOME LONG ARM; CARCINOMA IN-SITU; Y-CHROMOSOME; ALKALINE-PHOSPHATASE; TUMORS; DELETIONS; GENE; DIFFERENTIATION; SPERMATOGENESIS; HETEROGENEITY;
Keywords:
RBM; immunohistochemical marker; germ cell neoplasia; testis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Maymon, BBS Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Inst Pathol, 6 Weizman St, IL-64239 Tel Aviv, Israel Tel Aviv Univ 6 Weizman St Tel Aviv Israel IL-64239 v, Israel
Citazione:
B. Lifschitz-Mercer et al., "Absence of RBM expression as a marker of intratubular (in situ) germ cell neoplasia of the testis", HUMAN PATH, 31(9), 2000, pp. 1116-1120

Abstract

RBM (RNA-binding motif) protein is a marker of male germ cells. This protein is encoded by the Azoospermia factor region-b (AZF-b) of the human Y chromosome and is expressed exclusively in the male germ cell line, that is, spermatogonia, spermatocytes, and round spermatids. The authors analyzed theexpression of the RBM gene in germ cell tumors and in the seminiferous tubules in the vicinity of these tumors to identify the presence of IGCN. Sections from testicular germ cell tumors of 21 patients were stained with anti-RBM antibody by using an immunohistochemical method. Distal tubules showing spermatogenesis were immunopositive for RBM protein. All of the germ celltumors studied were completely immunonegative for RBM. Defined areas of IGCN also showed an absence of RBM:expression. Tubules with spermatocyte-likecells, which expected to express RBM, did not express this protein. This result enabled the identification of tubules as being IGCN. RBM is a novel marker consistently expressed in normal male germ cells but not in malignantgerm cell tumors or IGCN. Thus, the absence of RBM expression in germ cells provides a new diagnostic tool of preinvasive malignancy of the testis. Copyright (C) 2000 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 08:34:09