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Titolo:
CK7 expression in carcinomas of the Waldeyer's ring area
Autore:
Regauer, S; Beham, A; Mannweiler, S;
Indirizzi:
Graz Univ, Inst Pathol, Sch Med, A-8036 Graz, Austria Graz Univ Graz Austria A-8036 Inst Pathol, Sch Med, A-8036 Graz, Austria
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 9, volume: 31, anno: 2000,
pagine: 1096 - 1101
SICI:
0046-8177(200009)31:9<1096:CEICOT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL-CARCINOMA; HUMAN ORAL EPITHELIUM; BRANCHIOGENIC CARCINOMA; LUNG-CANCER; KERATIN EXPRESSION; CERVICAL-CANCER; CYTOKERATINS; CYFRA-21-1; MARKER; NECK;
Keywords:
palatine tonsil; base of tongue; intermediate filaments; basaloid SCC; minor salivary glands; oropharynx;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Regauer, S Graz Univ, Inst Pathol, Sch Med, Auenbruggerpl 25, A-8036 Graz,Austria Graz Univ Auenbruggerpl 25 Graz Austria A-8036 6 Graz, Austria
Citazione:
S. Regauer et al., "CK7 expression in carcinomas of the Waldeyer's ring area", HUMAN PATH, 31(9), 2000, pp. 1096-1101

Abstract

Primary carcinomas of the Waldeyer's ring area are typically nonkeratinizing squamous cell carcinomas (SCC). Their cervical lymph node metastases arenot uncommonly cystic and filled with necrotic tumor cells. Some cysts, however, contain clear fluid. During the investigation of SCC producing "fluid-filled" cystic metastases, we evaluated hematoxylin and eosin (H&E) sections of 90 primary SCC Tor their site of origin. We analyzed the cytokeratin(CK) profile of primary and metastatic carcinoma with special focus on theexpression of CK7, a putative marker for ductal differentiation. CK7 was expressed in submucosal minor salivary gland acini and ducts, but not in theSquamous surface epithelium of the Waldeyer's ring. CK7 was expressed in 11 primary SCC (8 base of tongue/3 palatine tonsil). The CK7-positive SCC were deep-seated, arose from large excretory ducts of submucosal minor salivary glands, and showed only insignificant surface involvement. They were characterized by a solid infiltrative growth pattern of basaloid cells with focal ductal differentiation. Salivary ducts adjacent to the carcinoma showedextensive intraductal hyperplasia and metaplasia. All CK7-positive carcinomas produced CK7-positive cystic nodal metastases, most of which contained paucicellular fluid. No solid CK7-positive nodal metastases were identified. In summary, a subset of carcinomas occurring in the Waldeyer's ring area appear to arise from large excretory ducts of submucosal minor salivary glands with only limited surface involvement, express CK7, and produce CK7-positive cystic "fluid-filled" nodal metastases. The histomorphology and immunophenotype suggest that these carcinomas represent basaloid SCC arising from excretory ducts of the submucosal minor salivary glands. Copyright (C) 2000 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:50:27