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Titolo:
Neuropsychological approaches to treatment policy issues in phenylketonuria
Autore:
Griffiths, P;
Indirizzi:
Univ Stirling, Dept Psychol, Stirling FK9 4LA, Scotland Univ Stirling Stirling Scotland FK9 4LA chol, Stirling FK9 4LA, Scotland
Titolo Testata:
EUROPEAN JOURNAL OF PEDIATRICS
, volume: 159, anno: 2000, supplemento:, 2
pagine: S82 - S86
SICI:
0340-6199(200010)159:<S82:NATTPI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY-TREATED PHENYLKETONURIA; CONTINUOUS PERFORMANCE-TEST; SUSTAINED ATTENTION; EXECUTIVE FUNCTION; PHENYLALANINE RESTRICTION; ADULT PHENYLKETONURIA; CHILDREN; DEFICITS; ADOLESCENTS; VIGILANCE;
Keywords:
diet therapy; neuropsychological assessment; phenylketonuria; treatment policy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Griffiths, P Univ Stirling, Dept Psychol, Stirling FK9 4LA, Scotland Univ Stirling Stirling Scotland FK9 4LA g FK9 4LA, Scotland
Citazione:
P. Griffiths, "Neuropsychological approaches to treatment policy issues in phenylketonuria", EUR J PED, 159, 2000, pp. S82-S86

Abstract

Neuropsychological research conducted so far on treatment factors in phenylketonuria suggests that dietary cessation at age 6 is too early. However, continuation of diet until age 10 appears to provide protection against subsequent hyperphenylalaninaemia in the domains of perception. memory and motor skill if concentrations remain at least below 1200 mu mol/l thereafter. Levels in the range 360 mu mol/l to 600 mu mol/l appear to constitute a hazard for executive skill during the pre-school period but in the primary school years the risk diminishes. Levels above 900 mu mol/l in early adolescence and adulthood may affect executive abilities adversely and the question remains whether such effects are reversible. Conclusion Though scant, neuropsychological evidence does not seriously contradict current British and German recommendations for dietary control in phenylketonuria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 10:00:22