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Titolo:
Cardiac dysfunction in acromegaly: evidence by pulsed wave tissue Doppler imaging
Autore:
Mercuro, G; Zoncu, S; Colonna, P; Cherchi, P; Mariotti, S; Pigliaru, F; Petrini, L; Iliceto, S;
Indirizzi:
Univ Cagliari, Dept Cardiovasc Sci, I-09124 Cagliari, Italy Univ CagliariCagliari Italy I-09124 iovasc Sci, I-09124 Cagliari, Italy Univ Cagliari, Dept Endocrinol, Cagliari, Italy Univ Cagliari Cagliari Italy Cagliari, Dept Endocrinol, Cagliari, Italy Univ Cagliari, Dept Med Sci, Cagliari, Italy Univ Cagliari Cagliari Italy iv Cagliari, Dept Med Sci, Cagliari, Italy
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 3, volume: 143, anno: 2000,
pagine: 363 - 369
SICI:
0804-4643(200009)143:3<363:CDIAEB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; M-MODE ECHOCARDIOGRAPHY; GROWTH-HORMONE; HEART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Mercuro, G Univ Cagliari, Dept Cardiovasc Sci, Via S Giorgio 12, I-09124 Cagliari, Italy Univ Cagliari Via S Giorgio 12 Cagliari Italy I-09124 i, Italy
Citazione:
G. Mercuro et al., "Cardiac dysfunction in acromegaly: evidence by pulsed wave tissue Doppler imaging", EUR J ENDOC, 143(3), 2000, pp. 363-369

Abstract

Objective: To verify whether the accuracy of data on myocardial function provided by pulsed-wave tissue Doppler imaging (PWTDI), a new echocardiographic application that allows quantitative measurements of myocardial wall velocities, could help torn ards a better understanding of the natural history of acromegalic cardiomyopathy. Design: Eighteen patients with active acromegaly (ten men and eight women;mean age 48.0 +/- 15.0 years) with no other detectable cause of heart disease underwent PWTDI. Thirteen healthy individuals matched for age and body mass index acted as a control group. Methods: Ejection fraction (EF), transmitral early/late diastolic velocity(E/A) ratio and isovolumic relaxation time (IVRT) were measured by conventional echocardiography; systolic peak (Sv) and early (Ev) and late (Av) diastolic peak velocities, Ev/Av ratio and regional IVRT (IVRTs) were obtainedby PWTDI. Results: All patients showed appreciably abnormal left ventricular global diastolic function represented by prolongation of the IVRT (P < 0.001). Using PWTDI we found a prolongation of IVRTs and inversion of the Ev/Av ratio. In addition, the Ev/Av ratio proved to be significantly negatively correlated with IVRT; this correlation was not present in the case of the E/A ratio. Furthermore, a decrease in Sv was detected in the basal segment of the lateral wall (P < 0.01), which had the greatest degree of diastolic dysfunction. Conclusions: PWTDI confirmed the acknowledged diastolic dysfunction that accompanies acromegalic cardiomyopathy and highlighted the greater sensitivity of regional PWTDI with respect to global Doppler diastolic indexes. Furthermore, by revealing an impairment of regional systolic function in presence of a normal EE the findings with PWTDI contradicted the largely acceptedtheory that systolic function remains normal for several years in patientsaffected by acromegalic cardiomyopathy.

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Documento generato il 04/12/20 alle ore 20:02:53