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Titolo:
Improved right ventricular function after intracoronary administration of a C1 esterase inhibitor in a right heart transplantation models
Autore:
Klima, U; Kutschka, I; Warnecke, G; Kim, P; Struber, M; Kirschfink, M; Haverich, A;
Indirizzi:
Hannover Med Sch, Dept Thorac & Cardiovasc Surg, D-3000 Hannover, Germany Hannover Med Sch Hannover Germany D-3000 Surg, D-3000 Hannover, Germany Univ Heidelberg, Inst Immunol, D-6900 Heidelberg, Germany Univ HeidelbergHeidelberg Germany D-6900 ol, D-6900 Heidelberg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
fascicolo: 3, volume: 18, anno: 2000,
pagine: 321 - 327
SICI:
1010-7940(200009)18:3<321:IRVFAI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC MYOCARDIUM; COMPLEMENT; ACCUMULATION; REPERFUSION; MECHANISM; INJURY;
Keywords:
myocardial protection; heart transplantation; right ventricular function; C1 esterase inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Klima, U Hannover Med Sch, Dept Thorac & Cardiovasc Surg, D-3000 Hannover,Germany Hannover Med Sch Hannover Germany D-3000 3000 Hannover, Germany
Citazione:
U. Klima et al., "Improved right ventricular function after intracoronary administration of a C1 esterase inhibitor in a right heart transplantation models", EUR J CAR-T, 18(3), 2000, pp. 321-327

Abstract

Objective: Myocardial injury from ischemia can be augmented after reperfusion due to proinflammatory events including complement activation, leukocyte adhesion, and release of various chemical mediators. It has been shown that intracoronary administration of a C1 esterase inhibitor (C1 INH) significantly reduces myocardial necrosis in an experimental model of ischemia. Our study addresses the question whether the most susceptible region of the heart for ischemic injury, the right ventricle (RV), can benefit from the protective effects of C1 esterase inhibition after transplantation. Methods: To precisely control RV volume in vivo an isovolumic model was used in which the RV volume was regulated using an intracavity high compliance balloon inserted into donor hearts of domestic pigs (34 +/- 4 kg). After 4 h of ischemia, donor hearts were transplanted into recipient pigs (44 +/- 4 kg). Treatment groups, each with six animals, consisted of C1 INH treatment or control. After opening the cross clamp, the C1 INH group animals received 20 IU/kg body weight of C1 INH intracoronary over a 5 min period. The control animals received no drug therapy. The hearts were reperfused for 60 min, andthereafter the RV balloon volume was increased in 10 ml increments until RV failure occurred. These measurements were repeated after 120 min of reperfusion. Results: There was no significant difference in maximal RV developed pressure between the two groups (after 1 h, 35.7 +/- 5.9 vs. 40.6 +/- 12.7 mmHg; after 2 h, 41.5 +/- 10.7 vs. 46.3 +/- 15.2 mmHg; for C1 INH and control animals, respectively). However, the RV could be loaded with a significantly higher volume after both 1 h (60.0 +/- 20.0 ml (C1 INH) vs. 46.7 +/-13.7 ml (control) balloon volume, P < 0.05), and 2 h of reperfusion (70.0 /- 8.9 ml vs. 60.0 +/- 6.3 ml; C1 INH and control animals, respectively; P< 0.05). Conclusions: Intracoronary administration of a C1 INH significantly improves right ventricular function in an experimental transplant model. Thus, inhibition of the classic complement cascade may be a promising therapeutic approach for effective protection of myocardium from reperfusion injury after transplantation. (C) 2000 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:37:17