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Titolo:
CYP2D6 gene polymorphism in Caucasian smokers: lung cancer susceptibility and phenotype-genotype relationships
Autore:
Laforest, L; Wikman, H; Benhamou, S; Saarikoski, ST; Bouchardy, C; Hirvonen, A; Dayer, P; Husgafvel-Pursiainen, K;
Indirizzi:
Finniah Inst Occupat Hlth, Dept Ind Hyg & Toxicol, Helsinki, Finland Finniah Inst Occupat Hlth Helsinki Finland & Toxicol, Helsinki, Finland Inst Gustave Roussy, INSERM, U521, Canc Epidemiol Unit, F-94805 Villejuif,France Inst Gustave Roussy Villejuif France F-94805 t, F-94805 Villejuif,France Geneva Canc Registry, Geneva, Switzerland Geneva Canc Registry Geneva Switzerland c Registry, Geneva, Switzerland Univ Hosp Geneva, Div Clin Pharmacol, Geneva, Switzerland Univ Hosp Geneva Geneva Switzerland Clin Pharmacol, Geneva, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 14, volume: 36, anno: 2000,
pagine: 1825 - 1832
SICI:
0959-8049(200009)36:14<1825:CGPICS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; IN-VIVO; EUROPEAN POPULATION; DEBRISOQUINE; SPARTEINE; TOBACCO; ALLELES; HYDROXYLATION; AMPLIFICATION; METABOLIZERS;
Keywords:
CYP2D6; lung cancer; tobacco smoking; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Husgafvel-Pursiainen, K Finniah Inst Occupat Hlth, Dept Ind Hyg & Toxicol,Helsinki, Finland Finniah Inst Occupat Hlth Helsinki Finland land
Citazione:
L. Laforest et al., "CYP2D6 gene polymorphism in Caucasian smokers: lung cancer susceptibility and phenotype-genotype relationships", EUR J CANC, 36(14), 2000, pp. 1825-1832

Abstract

Individual susceptibility to smoking-related cancers is proposed to partlydepend on a genetically determined ability to metabolise tobacco carcinogens. We previously reported on the association between the activity of the xenobiotic-metabolising enzyme CYP2D6 and lung cancer risk in a hospital-based case-control study among French Caucasian smokers. Here we extended the study to address the effect of four gene-inactivating mutations (CYP2D6*3, *4, *5 and *16) and the gene duplication of the CYP2D6 gene (CYP2D6*2x2 or CYP2D61*x2) on lung cancer risk in the same population (150 patients with primary lung carcinoma of squamous cell or small cell histology and 172 controls). The risk of lung cancer associated with the CYP2D6 poor metaboliser genotype (odds ratio 1.5, 95% confidence interval 0.5-4.3) did not differ from that in the reference category of extensive metaboliser and ultra-rapidmetaboliser genotypes combined. Lung cancer risks for the CYP2D6 PM genotype amongst light smokers (tobacco consumption less than or equal to 20 g/day) or heavy smokers (> 20 g/day) were not significantly different. The present findings agree with the discrepancy between the phenotype-based and genotype-based studies indicated by the recent meta-analyses. (C) 2000 Elsevier Science Ltd. All rights reserved.

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Documento generato il 23/01/20 alle ore 18:32:03