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Titolo:
ENDOTHELIN AND NITRIC-OXIDE IN HEPATORENAL-SYNDROME - A BALANCE RESET
Autore:
EPSTEIN M; GOLIGORSKY MS;
Indirizzi:
VET AFFAIRS MED CTR,NEPHROL SECT 1,1201 NW 16TH ST MIAMI FL 33125
Titolo Testata:
JN. Journal of nephrology
fascicolo: 3, volume: 10, anno: 1997,
pagine: 120 - 135
SICI:
1121-8428(1997)10:3<120:EANIH->2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL HYPERTENSIVE RATS; ALCOHOLIC LIVER-DISEASE; ACUTE-RENAL-FAILURE; BIG ENDOTHELIN-1; PLASMA ENDOTHELIN; CIRRHOTIC RATS; L-ARGININE; HYPERDYNAMIC CIRCULATION; ARTERIAL VASODILATION; SYNTHASE ACTIVITY;
Keywords:
ENDOTHELIN; LIVER DISEASE; RENAL FAILURE; NITRIC OXIDE; RENAL ISCHEMIA; HEPATORENAL SYNDROME; NO SYNTHASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
158
Recensione:
Indirizzi per estratti:
Citazione:
M. Epstein e M.S. Goligorsky, "ENDOTHELIN AND NITRIC-OXIDE IN HEPATORENAL-SYNDROME - A BALANCE RESET", JN. Journal of nephrology, 10(3), 1997, pp. 120-135

Abstract

The newly described endothelium-dependent vasoactive substances, nitric oxide and endothelins, have been the subject of intense investigative interest and have been demonstrated to promote a wide array of autocrine and. paracrine functions, Recent data highlight their emerging role as potential important mediators of renal failure in general, thussuggesting that they might also contribute to renal dysfunction In the setting of advanced hepatic disease, Most but no? all investigators,have demonstrated that circulating ET-I levels are elevated in patients with advanced liver disease, and some reports have suggested that the magnitude of the elevation correlates with the degree of renal dysfunction, Concomitantly, several investigators have demonstrated NO overproduction as assessed by elevated levels of NO2- and NO3- in patients with advanced liver disease, It has been suggested that serum nitrite/nitrate levels ape highest in patients with functional renal failure(i.e., HRS) and that these levels correlate with the magnitude of endotoxemia. Although large voids in our knowledge remain, the available evidence suggest that a reset balance between vasoconstrictor and vasodilatory stimuli may contribute to the renal hemodynamic abnormalitiesthat characterize the renal functional abnormalities of liver disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:39:37