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Titolo:
5-aminosalicylic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer
Autore:
Brown, WA; Farmer, KC; Skinner, SA; Malcontenti-Wilson, C; Misajon, A; OBrien, PE;
Indirizzi:
Monash Univ, Alfred Hosp, Dept Surg, Prahran, Vic 3181, Australia Monash Univ Prahran Vic Australia 3181 Surg, Prahran, Vic 3181, Australia
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 8, volume: 45, anno: 2000,
pagine: 1578 - 1584
SICI:
0163-2116(200008)45:8<1578:5AAOIT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL ADENOMATOUS POLYPOSIS; COLON CARCINOGENESIS; ULCERATIVE-COLITIS; CYCLOOXYGENASE-2 INHIBITOR; PROSTAGLANDIN SYNTHESIS; SULINDAC SULFONE; RAT; SULFASALAZINE; MODULATION; APOPTOSIS;
Keywords:
chemoprevention; colorectal cancer; 5-aminosalicylic acid; olsalazine; apoptosis; bromdeoxyuridine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, WA Monash Univ, Alfred Hosp, Dept Surg, Commercial Rd, Prahran, Vic3181, Australia Monash Univ Commercial Rd Prahran Vic Australia 3181 , Australia
Citazione:
W.A. Brown et al., "5-aminosalicylic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer", DIG DIS SCI, 45(8), 2000, pp. 1578-1584

Abstract

The ability of 5-aminosalicylic acid and olsalazine to inhibit colonic aberrant crypts and tumors was investigated in 1,2-dimethylhydrazine-treated rats. The effect of these drugs on the rates of tumor apoptosis and proliferation was studied as potential mechanisms for their action. 5-Aminosalicylic acid reduced the number of aberrant crypt foci by over one third, while olsalazine had no effect on this parameter. However, both agents effectivelyreduced tumor number and load, increased the rare of tumor apoptosis, and reduced the rate of tumor cell proliferation. In conclusion, 5-aminosalicylic acid and olsalazine are both ultimately effective chemopreventive agentsin this model; however, only 5-aminosalicylic acid inhibited the formationof aberrant crypt foci. The inhibitory effect of these agents in tumors isrelated to the inhibition of proliferation and the induction of apoptosis.

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Documento generato il 07/08/20 alle ore 07:04:39