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Titolo:
INCREASED SURFACE PHOSPHATIDYLSERINE IS AN EARLY MARKER OF NEURONAL APOPTOSIS
Autore:
RIMON G; BAZENET CE; PHILPOTT KL; RUBIN LL;
Indirizzi:
UNIV LONDON UNIV COLL,EISAI LONDON RES LABS LTD,BERNARD KATZ BLDG,GOWER ST LONDON WC1E 6BT ENGLAND UNIV LONDON UNIV COLL,EISAI LONDON RES LABS LTD LONDON WC1E 6BT ENGLAND
Titolo Testata:
Journal of neuroscience research
fascicolo: 6, volume: 48, anno: 1997,
pagine: 563 - 570
SICI:
0360-4012(1997)48:6<563:ISPIAE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; PROGRAMMED CELL-DEATH; FLOW CYTOMETRIC DETECTION; SYMPATHETIC NEURONS; PC12 CELLS; ANNEXIN-V; MACROPHAGES; EXPRESSION; RECOGNITION; ASSAY;
Keywords:
APOPTOSIS; PC12 CELLS; ICE-LIKE PROTEASES; FLIPPASES; PHOSPHATIDYLSERINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G. Rimon et al., "INCREASED SURFACE PHOSPHATIDYLSERINE IS AN EARLY MARKER OF NEURONAL APOPTOSIS", Journal of neuroscience research, 48(6), 1997, pp. 563-570

Abstract

Neuronal apoptosis is the subject of intense investigation and is beginning to be understood in some molecular detail, In the present study, we show that PC12 cells, like certain other cell types, redistributephosphatidylserine (PS) from the inner leaflet to the outer leaflet of the plasma membrane early ire the process of apoptosis, The externalised PS can be readily visualised by incubating intact cells with a fluorescent derivative of the protein annexin V. When apoptosis is blocked with an inhibitor of interleukin-1 beta-converting-enzyme-like proteases, the increased annexin binding is also blocked, Fluorescent annexin V binding provides a rapid and convenient way to identify apoptotic neurones. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:16:00