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Titolo:
Platelet supersensitivity to thrombin stimulation in depression: A possible mechanism for the association with cardiovascular mortality
Autore:
Berk, M; Plein, H;
Indirizzi:
Univ Witwatersrand, Fac Hlth Sci, Dept Psychiat, Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa Johannesburg, South Africa Univ Witwatersrand, Fac Hlth Sci, Dept Expt & Clin Pharmacol, Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa Johannesburg, South Africa
Titolo Testata:
CLINICAL NEUROPHARMACOLOGY
fascicolo: 4, volume: 23, anno: 2000,
pagine: 182 - 185
SICI:
0362-5664(200007/08)23:4<182:PSTTSI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR CALCIUM RESPONSE; ISCHEMIC-HEART-DISEASE; CORONARY-ARTERY DISEASE; MYOCARDIAL-INFARCTION; MAJOR DEPRESSION; PHOBIC ANXIETY; PANIC DISORDER; SEROTONIN; RISK; LEUKOENCEPHALOPATHY;
Keywords:
depression; mortality; thrombin; platelet; calcium; cardiovascular system;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Berk, M 7 York Rd, ZA-2193 Johannesburg, South Africa 7 York Rd Johannesburg South Africa ZA-2193 esburg, South Africa
Citazione:
M. Berk e H. Plein, "Platelet supersensitivity to thrombin stimulation in depression: A possible mechanism for the association with cardiovascular mortality", CLIN NEUROP, 23(4), 2000, pp. 182-185

Abstract

The mortality risk associated with cardiovascular disease is significantlyincreased in patients with major depression and panic disorder. The mechanism of this phenomenon is unclear. Thrombin is responsible for platelet aggregation and shape change, and it plays a significant role in the development of thromboembolic events. In this study, we examined the platelet secondmessenger intracellular calcium response to thrombin stimulation in patients with major depression (n = 13), major depression after response to electroconvulsive therapy( ECT; n = 13), subsyndromal depression (n = 16), schizophrenia (n = 15), and control subjects (n = 65). Patients with major depression had significantly higher intracellular calcium responses to thrombin stimulation than control subjects, patients with subsyndromal depression, and patients with schizophrenia (p < 0.05). Electroconvulsive therapy did not significantly change this supersensitivity. This suggests that the platelet response to activation in patients with major depression is supersensitive. This study suggests a possible mechanism for the increased risk of cardiovascular disease that is seen in these two psychiatric disorders. The lack of difference between the control and subsyndromal depression groups appears to validate current diagnostic thresholds in depression. The failure ofnonpharmacologic treatment to alter this marker suggests that it may be a trait marker of depression.

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Documento generato il 21/01/20 alle ore 00:59:09