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Titolo:
Dexmedetomidine and haemodynamic responses to acute central hypovolaemia in conscious rabbits
Autore:
Blake, DW; Ludbrook, J; Van Leeuwen, AF;
Indirizzi:
Univ Melbourne, Dept Pharmacol, Anaesthesia Res Unit, Parkville, Vic 3052,Australia Univ Melbourne Parkville Vic Australia 3052 Parkville, Vic 3052,Australia Univ Melbourne, Royal Melbourne Hosp, Dept Surg, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 10, volume: 27, anno: 2000,
pagine: 801 - 809
SICI:
0305-1870(200010)27:10<801:DAHRTA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMODYNAMIC-RESPONSE; CLONIDINE; SURGERY; DOGS; HEMORRHAGE; ANESTHESIA; REFLEX;
Keywords:
alpha-adrenoceptor agonists; arterial baroreceptors; dexmedetomidine; hypovolaemia; postoperative complications;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Blake, DW Univ Melbourne, Dept Pharmacol, Anaesthesia Res Unit, Parkville,Vic 3052,Australia Univ Melbourne Parkville Vic Australia 3052 Vic 3052,Australia
Citazione:
D.W. Blake et al., "Dexmedetomidine and haemodynamic responses to acute central hypovolaemia in conscious rabbits", CLIN EXP PH, 27(10), 2000, pp. 801-809

Abstract

1. Effects of the alpha(2)-adrenoceptor agonist dexmedetomidine on vasoconstrictor and heart rate (HR) responses to acute central hypovolaemia were studied in eight chronically instrumented rabbits. We compared intravenous (i.v.) and fourth ventricular (V-4) dexmedetomidine (0.1-10 mu g/kg) and thereversal of effects by the alpha(2)-adrenoceptor antagonist idazoxan and the opioid agonist alfentanil.2. Gradual inflation of an inferior vena cava (IVC) cuff reduced cardiac index (CI) by 8%/min, with progressive vasoconstriction and increased HR. Incontrol rabbits, at approximately 40% baseline CI, there was sudden decompensation with failure of vasoconstriction and a fall in mean arterial pressure (MAP).3. Dexmedetomidine (i.v. and V-4) reduced resting MAP and HR and caused anearlier decompensation during central hypovolaemia. Intravenous dexmedetomidine (3 and 10 mu g/kg) also reduced the slope of the initial vasoconstrictor response and the maximum HR.4. The effects of dexmedetomidine were reversed by the antagonist idazoxan, which prevented the decompensation phase. Intravenous alfentanil was alsoeffective in restoring the vasoconstrictor response and delaying decompensation with hypovolaemia after dexmedetomidine. Combining dexmedetomidine with an opioid, such as alfentanil, may provide the benefit of reduced sympathetic tone without increased risk of cardiovascular collapse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:15:00