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Titolo:
Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure
Autore:
Damas, JK; Eiken, HG; Oie, E; Bjerkeli, V; Yndestad, A; Ueland, T; Tonnessen, T; Geiran, OR; Aass, H; Simonsen, S; Christensen, G; Froland, SS; Attramadal, H; Gullestad, L; Aukrust, P;
Indirizzi:
Univ Oslo, Natl Hosp, Dept Cardiol, Div Heart & Lung Dis, Oslo, Norway Univ Oslo Oslo Norway Dept Cardiol, Div Heart & Lung Dis, Oslo, Norway Univ Oslo, Natl Hosp, Dept Cardiothorac Surg, Div Heart & Lung Dis, Oslo, Norway Univ Oslo Oslo Norway iothorac Surg, Div Heart & Lung Dis, Oslo, Norway Univ Oslo, Natl Hosp, Internal Med Res Inst, Oslo, Norway Univ Oslo OsloNorway o, Natl Hosp, Internal Med Res Inst, Oslo, Norway Univ Oslo, Natl Hosp, Dept Med, Sect Clin Immunol & Infect Dis, Oslo, Norway Univ Oslo Oslo Norway Med, Sect Clin Immunol & Infect Dis, Oslo, Norway Univ Oslo, Natl Hosp, Dept Med, Endocrinol Sect, Oslo, Norway Univ Oslo Oslo Norway atl Hosp, Dept Med, Endocrinol Sect, Oslo, Norway Univ Oslo, Natl Hosp, MSD Cardiovasc Res Ctr, Oslo, Norway Univ Oslo Oslo Norway , Natl Hosp, MSD Cardiovasc Res Ctr, Oslo, Norway Univ Oslo, Ulleval Hosp, Expt Med Res Inst, Oslo, Norway Univ Oslo Oslo Norway lo, Ulleval Hosp, Expt Med Res Inst, Oslo, Norway
Titolo Testata:
CARDIOVASCULAR RESEARCH
fascicolo: 4, volume: 47, anno: 2000,
pagine: 778 - 787
SICI:
0008-6363(200009)47:4<778:MEOCAC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; DILATED CARDIOMYOPATHY; CHEMOTACTIC CYTOKINES; ADHESION MOLECULES; GENE-EXPRESSION; CELL-DEATH; T-CELLS; X-C; APOPTOSIS; DISEASE;
Keywords:
cytokines; gene expression; heart failure; infection/inflammation; monoclonal antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Damas, JK Univ Oslo, Natl Hosp, Dept Cardiol, Div Heart & Lung Dis, Oslo, Norway Univ Oslo Oslo Norway iol, Div Heart & Lung Dis, Oslo, Norway
Citazione:
J.K. Damas et al., "Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure", CARDIO RES, 47(4), 2000, pp. 778-787

Abstract

Objectives: Chemokines regulate several biological processes, such as chemotaxis, collagen turnover, angiogenesis and apoptosis. Based on the persistent immune activation with elevated circulating levels of chemokines in patients with congestive heart failure (CHF), we have hypothesised a pathogenic role for chemokines in the development of CHF. The objective of this study was to examine mRNA levels and cellular localisation of chemokines and chemokine receptors in human CHF. Methods: We examined explanted hearts from ten patients with end-stage heart failure (all chambers) and in ten organ donors using an RNase protection assays and immunohistochemical techniques. Results: Our main findings were: (i) expression of eight chemokine and ninechemokine receptor genes in both failing and nonfailing myocardium, (ii) particularly high mRNA levels of monocyte chemoattractant protein (MCP)-1 and CXC-chemokine receptor 4 (CXCR4), in both chronic failing and nonfailing myocardium, (iii) decreased mRNA levels of MCP-I and interleukin (IL)-8 in the failing left ventricles compared to failing left atria, (iv) decreased chemokine (e.g., MCP-1 and IL-8) and increased chemokine receptor (e.g., CCR2, CXCR1) mRNA levels in failing left ventricles and failing left atria compared to corresponding chambers in the nonfailing hearts and (v) immunolocalisation of MCP-1, IL-8 and CXCR4 to cardiomyocytes. Conclusion: The present study demonstrates for the first time chemokine and chemokine receptor gene expression and protein localisation in the human myocardium, introducing a new family of mediators with potentially important effects on the myocardium. The observation of chemokine dysregulation in human end-stage heart failure may represent a previously unknown mechanism involved in progression of chronic heart failure. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/11/20 alle ore 16:18:53