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Titolo:
GFR alpha-1 is expressed in parvalbumin GABAergic neurons in the hippocampus
Autore:
Sarabi, A; Hoffer, BJ; Olson, L; Morales, M;
Indirizzi:
Natl Inst Drug Abuse, Baltimore, MD 21224 USA Natl Inst Drug Abuse Baltimore MD USA 21224 buse, Baltimore, MD 21224 USA Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska InstStockholm Sweden S-17177 osci, S-17177 Stockholm, Sweden
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 877, anno: 2000,
pagine: 262 - 270
SICI:
0006-8993(20000922)877:2<262:GAIEIP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-BINDING PROTEIN; KAINATE-INDUCED EXCITATION; C-RET PROTOONCOGENE; MICE LACKING GDNF; NEUROTROPHIC-FACTOR; RAT HIPPOCAMPUS; MESSENGER-RNAS; DOPAMINERGIC-NEURONS; IMMUNOCYTOCHEMICAL LOCALIZATION; INHIBITORY INTERNEURONS;
Keywords:
GDNF; interneurons; calcium-binding protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Morales, M Natl Inst Drug Abuse, 5500 Nathan Shock Dr, Baltimore, MD 21224USA Natl Inst Drug Abuse 5500 Nathan Shock Dr Baltimore MD USA 21224
Citazione:
A. Sarabi et al., "GFR alpha-1 is expressed in parvalbumin GABAergic neurons in the hippocampus", BRAIN RES, 877(2), 2000, pp. 262-270

Abstract

Glial cell line derived neurotrophic factor (GDNF) is a potent survival factor for several types of neurons. GDNF binds with high affinity to GDNF-family receptor alpha-1 (GFR alpha-1). This receptor is expressed in different areas of the brain, including the hippocampus and dentate gyrus. By usingin situ hybridization and immunohistochemistry, we found that 19% to 37% of glutamic acid decarboxylase (GAD) expressing neurons co-expressed GFR alpha-1 in the hippocampus. GFR alpha-1/GAD co-expression was found mainly in the stratum (s) pyramidale (29-37%) and s. oriens (20-25%). Further characterization of GFR alpha-1 expressing interneurons, based on their calcium-binding protein immunoreactivity, demonstrated that many parvalbumin (PV) immunoreactive neurons express GFR alpha-1 in the s. pyramidale of CA1 (72%), CA2 (70%) and CA3 (70%) subfields of the hippocampus. GFR alpha-1/PV doublelabeled neurons were also detected in the s. oriens of CA1 (52%), CA2 (27%) and CA3 (36%) subfields. The expression of GFR alpha-1 in principal neurons and in a specific sub-population of GABAergic neurons (PV-containing neurons) suggest that GDNF might modulate, in a selective manner, functions ofthe entire adult hippocampus. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:32:55