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Titolo:
Methodological issues in developing new acute treatments for patients withbipolar illness
Autore:
Rush, AJ; Post, RM; Nolen, WA; Keck, PE; Suppes, T; Altshuler, L; McElroy, SL;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 d Ctr, Dept Psychiat, Dallas, TX 75390 USA NIMH, Biol Psychiat Branch, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 , Biol Psychiat Branch, Bethesda, MD 20892 USA Univ Utrecht, Med Ctr, HC Rumke Grp, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands tr, HC Rumke Grp, Utrecht, Netherlands Univ Calif Los Angeles, Inst Neuropsychiat, Los Angeles, CA USA Univ CalifLos Angeles Los Angeles CA USA opsychiat, Los Angeles, CA USA W Los Angeles Vet Affairs Med Ctr, Los Angeles, CA 90073 USA W Los AngelesVet Affairs Med Ctr Los Angeles CA USA 90073 , CA 90073 USA Univ Cincinnati, Coll Med, Dept Psychiat, Biol Psychiat Program, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA l Psychiat Program, Cincinnati, OH USA Stanley Fdn Bipolar Network, Bethesda, MD USA Stanley Fdn Bipolar NetworkBethesda MD USA ar Network, Bethesda, MD USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 6, volume: 48, anno: 2000,
pagine: 615 - 624
SICI:
0006-3223(20000915)48:6<615:MIIDNA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPRESSIVE SYMPTOMATOLOGY IDS; PARTIAL-ONSET SEIZURES; ANTIEPILEPTIC DRUGS; LITHIUM TREATMENT; CONTROLLED TRIAL; WORKSHOP REPORT; DOUBLE-BLIND; DISORDER; MANIA; THERAPY;
Keywords:
acute phase treatment; bipolar illness; methodological issues;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Rush, AJ Univ Texas, SW Med Ctr, Dept Psychiat, 5323 Harry Hines Blvd 9086, Dallas,TX 75390 USA Univ Texas 5323 Harry Hines Blvd 9086 Dallas TX USA 75390 390 USA
Citazione:
A.J. Rush et al., "Methodological issues in developing new acute treatments for patients withbipolar illness", BIOL PSYCHI, 48(6), 2000, pp. 615-624

Abstract

One important aim of the recent reorganization of the National Institute of Mental Health (NIMH) is to streamline the development of new treatments for patients with severe mental illnesses, such as bipolar disorder, Researching new treatments for patients with bipolar disorder presents specific problems not readily addressed by traditional efficacy trial methodologies that aim to maximize internal validity. This article reexamines several assumptions that have guided the design of these efficacy trials but that also create obstacles for studies of bipolar disorder and suggests potential solutions. This article draws on literature from neurology and psychiatry and discussions at a MacArthur Foundation-sponsored Conference on Longitudinal Methodology in 1992 (David J. Kupfer, MD., Chair), which brought together investigators to consider alternative designs for patients with severe and persistent mental illness, In addition, we benefited from discussions at two NIMH-sponsored conferences, one held in 1989 (Prien and Potter 1990) and the other in 1994 (Prien and Rush 1996), at which investigators and methodologists discussed issues surrounding the development and conduct of informative efficacy trials for patients with bipolar disorder. Based on these discussions and recent literature reviews, we 1) outline common problems in the development and evaluation of effective acute treatments for bipolar disorder and 2) suggest possible solutions to these impediments. We also discuss alternative designs by which to build a sequence of acute treatment studiesfrom which efficacy, safety, and the comparative value of different treatments can be established (C) 2000 Society of Biological Psychiatry.

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Documento generato il 29/03/20 alle ore 15:13:56