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Titolo:
The significance of CD105, TGF beta and CD105/TGF beta complexes in coronary artery disease
Autore:
Li, CG; Bethell, H; Wilson, PB; Bhatnagar, D; Walker, MG; Kumar, S;
Indirizzi:
Univ Manchester, Sch Med, Dept Pathol Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Northwick Pk Hosp, Dept Cardiovasc Med, Harrow HA1 3UJ, Middx, England Northwick Pk Hosp Harrow Middx England HA1 3UJ ow HA1 3UJ, Middx, England St Marys Hosp, Dept Immunol, Manchester M13 0JH, Lancs, England St Marys Hosp Manchester Lancs England M13 0JH er M13 0JH, Lancs, England Manchester Royal Infirm, Dept Med, Manchester M13 0JH, Lancs, England Manchester Royal Infirm Manchester Lancs England M13 0JH , Lancs, England Manchester Royal Infirm, Dept Vasc Surg, Manchester M13 0JH, Lancs, England Manchester Royal Infirm Manchester Lancs England M13 0JH , Lancs, England
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 152, anno: 2000,
pagine: 249 - 256
SICI:
0021-9150(200009)152:1<249:TSOCTB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; SMOOTH-MUSCLE CELLS; ENDOTHELIAL-CELLS; TUMOR VASCULATURE; BREAST-CARCINOMA; ENDOGLIN; ATHEROSCLEROSIS; EXPRESSION; PROTEIN; PLASMA;
Keywords:
atherosclerosis; CD105; TGF beta; receptor-ligand complexes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kumar, S Univ Manchester, Sch Med, Dept Pathol Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT Lancs, England
Citazione:
C.G. Li et al., "The significance of CD105, TGF beta and CD105/TGF beta complexes in coronary artery disease", ATHEROSCLER, 152(1), 2000, pp. 249-256

Abstract

We have quantified levels of CD105, its ligand TGF beta and receptor-ligand complexes in sera from healthy individuals (n = 31), patients with triplevessel disease documented by coronary angiography (TVD; n = 36) and patients with chest pain and a positive exercise electrocardiogram but with normal coronary angiogram (NCA; n = 30). Both active TGF beta 1 and active plus acid-activatable TGF beta 1 [(a + 1)TGF beta 1] were significantly depressed in patients with TVD compared with the other two groups (P less than or equal to 0.04). CD105 levels in TVD patients were also diminished but elevated in NCA patients. In contrast, patients with TVD had more CD105/TGF beta 1 complex in their sera than the other two groups, suggesting that this maybe the reason why TVD patients had low levels of receptor and ligand. TGF beta 3 levels were similar in the three groups, but elevated CD105/TGF beta3 levels were noted in patients with NCA compared with those with TVD and healthy individuals (P less than or equal to 0.02). CD105 was correlated with both active TGF beta 1 and (a + 1)TGF beta 1 (P = 0.02). CD105 also strongly correlated with TGF beta 3 and CD105/TGF beta 3 complexes (P = 0.001 in both cases). The changes in levels of CD105, TGF beta 1 and the receptor-ligand complexes in sera of patients with atherosclerosis suggest that these molecules may be important in the pathobiology of the atherosclerotic disease. Further studies on sequential samples from a larger cohort of patients are needed to define a causal relationship between these molecules and the disease progression. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:38:07