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Titolo:
Growth hormone attenuates alterations in spinal cord evoked potentials andcell injury following trauma to the rat spinal cord - An experimental study using topical application of rat growth hormone
Autore:
Winkler, T; Sharma, HS; Stalberg, E; Badgaiyan, RD; Westman, J; Nyberg, F;
Indirizzi:
Uppsala Univ, Biomed Ctr, Dept Med Cell Biol, Lab Neuroanat, SE-75123 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75123 Neuroanat, SE-75123 Uppsala, Sweden Univ Uppsala Hosp, Dept Clin Neurophysiol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 hysiol, S-75185 Uppsala, Sweden Uppsala Univ, Biomed Ctr, Dept Pharmaceut Biosci, Div Biol Res Drug Dependence, Uppsala, Sweden Uppsala Univ Uppsala Sweden v Biol Res Drug Dependence, Uppsala, Sweden
Titolo Testata:
AMINO ACIDS
fascicolo: 1, volume: 19, anno: 2000,
pagine: 363 - 371
SICI:
0939-4451(2000)19:1<363:GHAAIS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; NITRIC-OXIDE SYNTHASE; FACTOR-I; NEUROTROPHIC FACTOR; UP-REGULATION; BRAIN; EDEMA;
Keywords:
amino acids; growth hormone; spinal cord injury; edema formation; spinal cord evoked potentials; spinal cord edema; cell injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Sharma, HS Uppsala Univ, Biomed Ctr, Dept Med Cell Biol, Lab Neuroanat, Box 571, SE-75123 Uppsala, Sweden Uppsala Univ Box 571 Uppsala Sweden SE-75123 3 Uppsala, Sweden
Citazione:
T. Winkler et al., "Growth hormone attenuates alterations in spinal cord evoked potentials andcell injury following trauma to the rat spinal cord - An experimental study using topical application of rat growth hormone", AMINO ACIDS, 19(1), 2000, pp. 363-371

Abstract

The influence of exogenous rat growth hormone on spinal cord injury induced alterations in spinal cord evoked potentials (SCEP) and edema formation was examined in a rat model. Repeated topical application of rat growth hormone (20 mu l of 1 mu g/ml solution) applied 30 min before injury and at 0 min (at the time of injury), 10 min, 30 min, 60 min, 120 min, 180 min, and 240 min, resulted in a marked preservation of SCEP amplitude after injury. In addition, the treated traumatised cord showed significantly less edema and cell changes. These observations suggest that growth hormone has the capacity to improve spinal cord conduction and attenuate edema formation and cell injury in the cord indicating a potential therapeutic implication of this peptide in spinal cord injuries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:48:28