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Titolo:
Electrophysiological effects of exogenous and endogenous kynurenic acid inthe rat brain: studies in vivo and in vitro
Autore:
Scharfman, HE; Goodman, JH; Schwarcz, R;
Indirizzi:
Helen Hayes Hosp, Neurol Res Ctr, W Haverstraw, NY 10993 USA Helen Hayes Hosp W Haverstraw NY USA 10993 tr, W Haverstraw, NY 10993 USA Columbia Univ Coll Phys & Surg, Dept Pharmacol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USAUniv Maryland Baltimore MD USA 21201 iat Res Ctr, Baltimore, MD 21201 USA
Titolo Testata:
AMINO ACIDS
fascicolo: 1, volume: 19, anno: 2000,
pagine: 283 - 297
SICI:
0939-4451(2000)19:1<283:EEOEAE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTORS; PAIRED-PULSE DEPRESSION; CELL FIELD POTENTIALS; GYRUS GRANULE CELLS; NMDA RECEPTORS; QUINOLINIC ACID; DENTATE GYRUS; EPILEPTIFORM ACTIVITY; PERFORANT PATH; GLYCINE SITE;
Keywords:
amino acids; anticonvulsant; entorhinal cortex; glycine; hippocampus; N-methyl-D-aspartate; tryptophan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Scharfman, HE Helen Hayes Hosp, Neurol Res Ctr, Rte 9W, W Haverstraw, NY 10993 USA Helen Hayes Hosp Rte 9W W Haverstraw NY USA 10993 10993 USA
Citazione:
H.E. Scharfman et al., "Electrophysiological effects of exogenous and endogenous kynurenic acid inthe rat brain: studies in vivo and in vitro", AMINO ACIDS, 19(1), 2000, pp. 283-297

Abstract

In this review, recent studies on the electrophysiological effects of de novo synthesized ("endogenous") kynurenic acid (KYNA) are discussed. Endogenous KYNA is normally formed as a byproduct of tryptophan metabolism Evidence for a physiological role in neuronal excitability has not been strong, inpart because brain levels are much lower than the K-D of KYNA at the glycine site of the NMDA receptor, where KYNA is thought to exert its most potent effect. The results suggest that, unexpectedly, even low concentrations of endogenous KYNA have physiological consequences. These levels of KYNA reduced the number of hippocampal slices with spontaneous epileptiform discharges after exposure to buffer lacking magnesium. However, effects on evoked responses to single afferent stimuli were not detected. Taken together, thedata argue for a potentially important role of endogenous KYNA in suppression of seizure-like activity, and suggest a novel approach to anticonvulsant drug development that could have few side effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:04:07