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Titolo:
Possible mediation of quinolinic acid-induced hippocampal damage by reactive oxygen species
Autore:
Stone, TW; Behan, WMH; MacDonald, M; Darlington, LG;
Indirizzi:
Univ Glasgow, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G12 8QQ ow G12 8QQ, Lanark, Scotland Univ Glasgow, Dept Pathol, Glasgow G12 8QQ, Lanark, Scotland Univ GlasgowGlasgow Lanark Scotland G12 8QQ ow G12 8QQ, Lanark, Scotland Epsom Gen Hosp, Surrey, England Epsom Gen Hosp Surrey EnglandEpsom Gen Hosp, Surrey, England
Titolo Testata:
AMINO ACIDS
fascicolo: 1, volume: 19, anno: 2000,
pagine: 275 - 281
SICI:
0939-4451(2000)19:1<275:PMOQAH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LIPID-PEROXIDATION; METHYL-D-ASPARTATE; (-)DEPRENYL INCREASES ACTIVITIES; PROTECTS PRIMARY CULTURES; RAT-BRAIN; SUPEROXIDE-DISMUTASE; NEURITE OUTGROWTH; RADICAL FORMATION; OXIDATIVE STRESS; KYNURENIC ACID;
Keywords:
amino acids; quinolinic acid; kynurenines; melatonin; deprenyl; antioxidants; free radicals; reactive oxygen species; neuroprotection; neurotoxicity; excitotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Stone, TW Univ Glasgow, Inst Biomed & Life Sci, W Med Bldg, Glasgow G12 8QQ, Lanark,Scotland Univ Glasgow W Med Bldg Glasgow Lanark Scotland G12 8QQ Scotland
Citazione:
T.W. Stone et al., "Possible mediation of quinolinic acid-induced hippocampal damage by reactive oxygen species", AMINO ACIDS, 19(1), 2000, pp. 275-281

Abstract

Several differences exist between quinolinic acid and N-methyl-D-aspartate(NMDA) in the potency and pharmacology of their neurotoxic actions in the brain, suggesting that quinolinic acid may act by mechanisms additional to the activation of NMDA receptors, possibly involving lipid peroxidation. Inthe present review,studies are considered which have attempted to determine whether free radicals might contribute to the neuronal damage induced by quinolinic acid. Following Injections into the hippocampus of anaesthetisedrats, quinolinic acid induced damage is prevented by melatonin, by an action not blocked by the melatonin receptor blocker luzindole. Deprenyl, but not the non-selective monoamine oxidase inhibitor nialamide, also prevent quinolinic acid-induced damage. In vitro, seversl groups have shown that quinolinic acid can induce lipid peroxidation of brain tissue The results suggest that free radical formation contributes significantly to quinolinic acid-induced damage in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:12:41