Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Drug treatments to reduce excitotoxicity in vivo: a potential for alpha 2-adrenoceptor antagonists?
Autore:
Martel, JC; Chopin, P; Colpaert, F; Marien, M;
Indirizzi:
Ctr Rech Pierre Fabre, Div Neurobiol 1, F-81106 Castres, France Ctr Rech Pierre Fabre Castres France F-81106 1, F-81106 Castres, France
Titolo Testata:
AMINO ACIDS
fascicolo: 1, volume: 19, anno: 2000,
pagine: 239 - 252
SICI:
0939-4451(2000)19:1<239:DTTREI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; ADRENERGIC-RECEPTOR REGULATION; LOCUS-COERULEUS LESIONS; METHYL-D-ASPARTATE; RAT-BRAIN; NEURODEGENERATIVE DISORDERS; NORADRENALINE DEPLETION; PARKINSONS-DISEASE; ENERGY-METABOLISM; STRIATAL DOPAMINE;
Keywords:
amino acids; excitotoxicity; quinolinic acid; intracerebral microdialysis; alpha(2)-adrenoceptor antagonists; neuroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Martel, JC Ctr Rech Pierre Fabre, Div Neurobiol 1, 17 Ave Jean Moulin, F-81106 Castres, France Ctr Rech Pierre Fabre 17 Ave Jean Moulin Castres France F-81106
Citazione:
J.C. Martel et al., "Drug treatments to reduce excitotoxicity in vivo: a potential for alpha 2-adrenoceptor antagonists?", AMINO ACIDS, 19(1), 2000, pp. 239-252

Abstract

It is hypothesized that the locus coeruleus-noradrenergic system controls compensatory and repair mechanisms in the CNS, and that its dysfunction is a critical factor in the progression of central neurodegenerative diseases. Pharmacological activation of locus coeruleus neurons can be achieved withalpha(2)-adrenoceptor antagonists, and such compounds are protective in vivo in some models of brain injury where excitotoxicity is thought to be a causative factor. To further explore this neuroprotective potential, the effects of a 7-day treatment with the alpha(2)-antagonists, (+)-efaroxan and (/-)-idazoxan, were evaluated in rats undergoing a unilateral lesioning of the striatum with the excitotoxin, quinolinic acid. The alpha(2)-antagonisttreatments reduced both the ipsiversive circling response to apomorphine and the deficit of choline acetyltransferase in the lesioned animals. To elucidate the mechanisms underlying this neuroprotective effect, a modulation of the extracellular levels of amino acids within the striatum was investigated using in vivo microdialysis. Intrastriatal injection of quinolinic acid increased taurine and tyrosine levels by 2-2.5 fold, while most other amino acids were not significantly altered; the effect of (+)-efaroxan on these changes is being investigated. Further research is required to identify which of several possible mechanisms is involved in the neuroprotective action of alpha(2)-antagonists in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:50:03