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Titolo:
Atypical antipsychotic-like effect of AMPA receptor antagonists in the rat
Autore:
Svensson, TH; Mathe, JM;
Indirizzi:
Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 ol, SE-17177 Stockholm, Sweden
Titolo Testata:
AMINO ACIDS
fascicolo: 1, volume: 19, anno: 2000,
pagine: 221 - 226
SICI:
0939-4451(2000)19:1<221:AAEOAR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED AVOIDANCE-RESPONSE; DIZOCILPINE MK-801; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; HYPERLOCOMOTION; NEUROLEPTICS; STEREOTYPY; ACTIVATION; BLOCKADE; ACID;
Keywords:
amino acids; conditioned avoidance response; AMPA; kainate; behavior; antipsychotic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Svensson, TH Karolinska Inst, Sect Neuropsychopharmacol, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 Stockholm, Sweden
Citazione:
T.H. Svensson e J.M. Mathe, "Atypical antipsychotic-like effect of AMPA receptor antagonists in the rat", AMINO ACIDS, 19(1), 2000, pp. 221-226

Abstract

Systemic administration of two chemically different AMPA receptor antagonists, GYKI52466, 20mg/kg, and LY326325, 18mg/kg, given subcutaneously, caused a selective suppression of conditioned avoidance response in the rat withpreservation of escape behavior. The number of intertrial crosses was not affected and no catalepsy was observed. These experimental results indicate, in principle, an antipsychotic effect of AMPA receptor antagonists with alow liability for extrapyramidal side effects and, consequently, a pharmacological profile consonant with atypical antipsychotic drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:33:08