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Titolo:
Cell-type specificity of mGluR activation in striatal neuronal subtypes
Autore:
Pisani, A; Bernardi, G; Bonsi, P; Centonze, D; Giacomini, P; Calabresi, P;
Indirizzi:
Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 eurol Clin, I-00133 Rome, Italy IRCCS Osped S Lucia, Rome, Italy IRCCS Osped S Lucia Rome ItalyIRCCS Osped S Lucia, Rome, Italy Univ La Sapienza, Neurol Clin 2, Rome, Italy Univ La Sapienza Rome Italy niv La Sapienza, Neurol Clin 2, Rome, Italy
Titolo Testata:
AMINO ACIDS
fascicolo: 1, volume: 19, anno: 2000,
pagine: 119 - 129
SICI:
0939-4451(2000)19:1<119:CSOMAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; HUNTINGTONS-DISEASE; NEOSTRIATAL NEURONS; BASAL GANGLIA; MEMBRANE EXCITABILITY; INTRINSIC CONTROL; RAT NEOSTRIATUM; MESSENGER-RNA; INTERNEURONS; LOCALIZATION;
Keywords:
amino acids; striatum; electrophysiology; metabotropic glutamate receptors; excitotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Pisani, A Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, Via Tor Vergata135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata 135 Rome Italy I-00133 ly
Citazione:
A. Pisani et al., "Cell-type specificity of mGluR activation in striatal neuronal subtypes", AMINO ACIDS, 19(1), 2000, pp. 119-129

Abstract

The effects of metabotropic glutamate receptor (mGluR) activation were studied in medium spiny neurons and large aspiny (LA) interneurons by means ofelectrophysiological and optical recordings. DCG-IV and L-SOP, agonists for group II and III mGluRs, respectively, produced a presynaptic inhibitory effect on corticostriatal glutamatergic excitatory postsynaptic potentials (EPSPs) in both spiny and LA cells. Activation of group I mGluRs by the selective agonist 3,5-DHPG produced no effect on membrane properties and glutamatergic transmission in spiny neurons, whereas it did cause a membrane depolarization in LA interneurons coupled to increased input resistance. In combined optical and electrophysiological experiments, in spiny neurons 3,5-DHPG enhanced membrane depolarization and intracellular calcium (Ca2+) levels induced by NMDA applications, but not in LA interneurons. These data suggest the existence of a positive interaction between NMDA and group I mGlu receptors only in medium spiny cells which might, at least partially, account for the differential vulnerability to excitotoxic damage observed in striatal neuronal subtypes.

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Documento generato il 11/07/20 alle ore 04:48:29