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Titolo:
The role of metabotropic glutamate receptor (mGluR) ligands in parkinsonian muscle rigidity
Autore:
Wolfarth, S; Konieczny, J; Lorenc-Koci, E; Ossowska, K; Pilc, A;
Indirizzi:
Polish Acad Sci, Dept Neuropsychopharmacol, Inst Pharmacol, PL-313434 Krakow, Poland Polish Acad Sci Krakow Poland PL-313434 rmacol, PL-313434 Krakow, Poland Polish Acad Sci, Inst Pharmacol, Dept Neurobiol, PL-313434 Krakow, Poland Polish Acad Sci Krakow Poland PL-313434 robiol, PL-313434 Krakow, Poland
Titolo Testata:
AMINO ACIDS
fascicolo: 1, volume: 19, anno: 2000,
pagine: 95 - 101
SICI:
0939-4451(2000)19:1<95:TROMGR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCINE SITE; NUCLEUS-ACCUMBENS; NMDA RECEPTOR; RATS; ANTAGONIST; STRIATUM; BACLOFEN; DISEASE; MK-801; TONE;
Keywords:
amino acids; Parkinsonian-like muscle rigidity; ionotropic glutamate receptors; metabotropic glutamate receptors; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Wolfarth, S Polish Acad Sci, Dept Neuropsychopharmacol, Inst Pharmacol, 12Smetna St, PL-313434 Krakow, Poland Polish Acad Sci 12 Smetna St Krakow Poland PL-313434 , Poland
Citazione:
S. Wolfarth et al., "The role of metabotropic glutamate receptor (mGluR) ligands in parkinsonian muscle rigidity", AMINO ACIDS, 19(1), 2000, pp. 95-101

Abstract

It has been shown that the primary striatal dopaminergic hypofunction which is at the origin of Parkinson's disease, results in a secondary hyperactivity of glutamatergic neurotransmission. In the search for a therapy of Parkinson's disease, ionotropic, mainly NMDA, receptor antagonists were found to have moderately beneficial, yet also some undesirable side-effects. Therefore the present study was aimed at determining whether some metabotropic glutamate receptor (mGluR) ligands may have antiparkinsonian effects in thehaloperidol-induced muscle rigidity. To this end three mGluR ligands were used: the potent and selective mGluR I antagonist (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA), the mixed group II agonist/group I antagonist (S)-4-carboxy-3-hydroxyphenyl-glycine ((S)-4-C3HPG), and the potent group II agonist (+)-2-aminobicyclo[3.1.0.]hexane-2,6,dicarboxylic acid (LY354740). OnlyLY354740 penetrated the brain from the periphery; for this reason other drugs were injected bilaterally into the rostral striatum or nucleus accumbens. The muscle tone was recorded by a mechanomyographic/electromyographic (MMG/EMG) method which measured the resistance of a rat's hind foot and the EMG reflex response of its muscles to passive movements. (S)-4C3KPG (5 and 15 mu g/0.5 mu l) and LY354740 (5 and 10 mg/kg i.p.) diminished the muscle rigidity induced by haloperidol (1 mg/kg i.p.). AIDA (0.5-15 mu g/0.5 mu l) injected into the striatum was only slightly effective in the highest dose used. However, when injected into the nucleus accumbens AIDA (15 mu g/0.5 mu l) significantly and strongly counteracted the haloperidol-induced musclerigidity. Our results suggest that stimulation of group II striatal mGluRsseems to play a major role in diminution of parkinsonian-like muscle rigidity. However, it seems that the antagonism of group I mGluRs located in thenucleus accumbens may also be of importance to the antiparkinsonian effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:14:12